2-Deoxy-D-glucose , 98% , 154-17-6

Synonym(s):
2-Deoxy-D-arabinohexose;2-Deoxyglucose

CAS NO.：154-17-6

Empirical Formula: C6H12O5

Molecular Weight: 164.16

MDL number: MFCD00151328

EINECS: 205-823-0

PRODUCT Properties

• Melting point: 146-147 °C(lit.)
• alpha: 45.5 º (c=2, H2O)
• Boiling point: 211.61°C (rough estimate)
• Density: 1.1738 (rough estimate)
• refractive index: 46.5 ° (C=1, H2O)
• storage temp.: 2-8°C
• solubility: H₂O: 50 mg/mL, clear, colorless to faintly yellow
• form: crystalline
• pka: pK1:12.52 (25°C)
• color: white
• optical activity: +38.5 → +45.9
• Water Solubility: Soluble in water.
• Merck: 14,2904
• BRN: 1723331
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. Solutions in water are not stable and must be used within 1 working day.
• InChIKey: PMMURAAUARKVCB-CEZCPVKQSA-N
• LogP: -1.460 (est)

Description and Uses

2-Deoxy-D-glucose (154-17-6) is a synthetic glucose analog with extensive biological effects. It is commonly thought of as an inhibitor of glycolysis, but its metabolic effects are wide-ranging. 2-Deoxy-D-glucose competitively inhibits glucose uptake via its metabolite 2-Deoxy-D-glucose-6-phosphate, which inhibits hexokinase and phosphoglucose-isomerase leading to decreased ATP production, cell cycle blockage, decreased cell growth and ultimately cell death.1,2

2-Deoxy-D-glucose (2-DG) is used in glucoprivic feeding research to invoke and study the processes of counter-regulatory response (CRR). 2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
• Hazard Codes: Xn,Xi
• Risk Statements: 20/21/22-36/37/38
• Safety Statements: 24/25-37/39-36-26
• WGK Germany: 3
• RTECS: MQ3325000
• F: 3-10
• TSCA: Yes
• HS Code: 29400090