Ursodeoxycholic acid , Analysis standard , 128-13-2

Synonym(s):
3α,7β-Dihydroxy-5β-cholan-24-oic acid;5β-Cholan-24-oic acid-3α,7β-diol;7β-Hydroxylithocholic acid;UDCS;Ursodeoxycholic acid

CAS NO.：128-13-2

Empirical Formula: C24H40O4

Molecular Weight: 392.57

MDL number: MFCD00003680

EINECS: 204-879-3

PRODUCT Properties

• Melting point: 203-204 °C (lit.)
• Boiling point: 437.26°C (rough estimate)
• alpha: 60 º (c=2, EtOH)
• Density: 0.9985 (rough estimate)
• refractive index: 60.5 ° (C=2, EtOH)
• Flash point: 9℃
• storage temp.: 2-8°C
• solubility: ethanol: 50 mg/mL, clear
• pka: pKa 5.04±0.04(H2O t = 25.0±0.1 I = 0.00)(Approximate)
• form: Solid. Powder.
• color: White - almost white.
• Water Solubility: practically insoluble
• Merck: 14,9889
• BRN: 3219888
• InChIKey: RUDATBOHQWOJDD-UZVSRGJWSA-N
• LogP: 3-3.38 at 20℃
• CAS DataBase Reference: 128-13-2(CAS DataBase Reference)

Description and Uses

Ursodeoxycholic acid (UDCS) is a cell protectant used extensively to mitigate hepatic and biliary diseases. Ursodeoxycholic acid may be used to study its specific activities that range from reduction of cholesterol absorpition, cholesterol gallstone dissolution to suppression of immune response. It is also used as an anticholelithogenic. Epimer with Chenodiol with respect to the hydroxyl group at C7.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 24/25-36-26
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 2
• RTECS: FZ2000000
• F: 10
• HS Code: 29181990
• Toxicity: LD50 in mice (g/kg): 0.1 i.v. (Ardenne, Reitnauer); in rats, mice (mg/kg): 2000, 6000 s.c.; 1000, 1200 i.p., 310, 260 i.v. (Ward)