A2769212
4-chloro-7-methoxyquinoline-6-carboxamide , 97% , 417721-36-9
CAS NO.：417721-36-9
Empirical Formula: C11H9ClN2O2
Molecular Weight: 236.65
MDL number: MFCD13192256
EINECS: 000-000-0
| Pack Size | Price | Stock | Quantity |
| 1G | RMB142.40 | In Stock |
|
| 5g | RMB451.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | >205°C (dec.) |
| Boiling point: | 426.7±45.0 °C(Predicted) |
| Density | 1.380±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 15.28±0.30(Predicted) |
| form | Solid |
| color | Off-White to Light Beige |
| InChI | InChI=1S/C11H9ClN2O2/c1-16-10-5-9-6(4-7(10)11(13)15)8(12)2-3-14-9/h2-5H,1H3,(H2,13,15) |
| InChIKey | ZBTVNIDMGKZSGC-UHFFFAOYSA-N |
| SMILES | N1C2C(=CC(C(N)=O)=C(OC)C=2)C(Cl)=CC=1 |
| CAS DataBase Reference | 417721-36-9 |
Description and Uses
4-chloro-7-Methoxyquinoline-6-carboxaMide is a pharmaceutical intermediate compound used in the preparation of Lenvatinib, an oral multi-receptor tyrosine kinase inhibitor approved by the FDA for the treatment of radioiodine-refractory differentiated thyroid cancer (DTC), unresectable (DTC), unresectable hepatocellular carcinoma (HCC), and advanced renal cell carcinoma (RCC).
Pharmaceutical Intermediates. 4-chloro-7-Methoxyquinoline-6-carboxaMide is used as an intermediate for synthesizing Lenvatinibis.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933499090 |
