Cedrol , >98.0%(GC) , 77-53-2

Synonym(s):
(1S,2R,5S,7R,8R)-2,6,6,8-Tetramethyltricyclo[5.3.1.0^1.5]undecan-8-ol

CAS NO.：77-53-2

Empirical Formula: C15H26O

Molecular Weight: 222.37

MDL number: MFCD00062952

EINECS: 201-035-6

PRODUCT Properties

• Melting point: 55-59 °C(lit.)
• Boiling point: 273 °C(lit.)
• alpha: D28 +9.9° (c = 5 in chloroform)
• Density: 0.9479
• refractive index: n20/D1.509-1.515
• FEMA: 4503 | (+)-CEDROL
• Flash point: 200 °F
• storage temp.: 2-8°C
• solubility: Soluble in DMSO (10 mg/ml)
• pka: 15.35±0.60(Predicted)
• form: Solid
• color: White
• Odor: at 100.00 %. cedarwood woody dry sweet soft
• Odor Type: woody
• optical activity: [α]20/D +10.5±1°, c = 5% in chloroform
• JECFA Number: 2030
• Merck: 14,1911
• BRN: 2206347
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
• LogP: 4.33

Description and Uses

Cedrol is a sesquiterpene alcohol found in conifers mainly of the genera Cupressus, Juniperus, and Cedrus. It has been found to possess significant anticancer activity against glioblastoma in vitro and in vivo via cell growth inhibition, ROS generation, and DNA damage.1 Cedrol also displayed synergistic effects with temozolomide against glioblastoma in vitro and in vivo via reduced expression of drug resistance proteins.1,2 Cedrol inhibited the growth of human renal adenocarcinoma and amelanotic melanoma cells3 and induced autophagy and apoptosis in A549 non-small cell lung carcinoma cells4.

acaricide, enhances skin ECM production

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
• Safety Statements: 22-24/25
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 2
• RTECS: PB7728666
• HS Code: 29062990
• Toxicity: LD50 skin in rabbit: > 5gm/kg