Chlorambucil , >98.0% , 305-03-3

Synonym(s):
4-(4-[Bis(2-chloroethyl)amino]phenyl)butyric acid;4-[Bis(2-chloroethyl)amino]benzenebutyric acid;Chlorambucil

CAS NO.：305-03-3

Empirical Formula: C14H19Cl2NO2

Molecular Weight: 304.21

MDL number: MFCD00021783

EINECS: 206-162-0

PRODUCT Properties

• Melting point: 65-70 °C
• Boiling point: 460.1±40.0 °C(Predicted)
• Density: 1.2486 (rough estimate)
• refractive index: 1.6070 (estimate)
• storage temp.: 2-8°C
• solubility: Practically insoluble in water, freely soluble in acetone and in ethanol (96 per cent).
• pka: pKa ～1.3(H2O) (Uncertain)
• form: Solid
• color: White to Light yellow
• Water Solubility: <0.01 g/100 mL at 22 ºC
• λmax: 588nm(DMSO aq.)(lit.)
• Merck: 14,2073
• BRN: 999011
• BCS Class: 3/1
• Stability: Stable, but may be light sensitive. Store cold. Incompatible with strong oxidizing agents.
• InChIKey: JCKYGMPEJWAADB-UHFFFAOYSA-N
• CAS DataBase Reference: 305-03-3(CAS DataBase Reference)
• NIST Chemistry Reference: Chlorambucil(305-03-3)
• IARC: 1 (Vol. 26, Sup 7, 100A) 2012
• EPA Substance Registry System: Chlorambucil (305-03-3)

Description and Uses

Chlorambucil, approved by the Food and Drug Administration (FDA) in 1957, is an antineoplastic/alkylating agent with a broad spectrum of antitumor activity used to treat chronic lymphocytic leukemia (CLL), Hodgkin’s and non-Hodgkin’s lymphomas.

tranquilization aid

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H301-H315-H319-H335-H350
• Precautionary statements: P201-P202-P261-P301+P310-P302+P352-P305+P351+P338
• Hazard Codes: T
• Risk Statements: 45-25-36/37/38
• Safety Statements: 53-26-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: ES7525000
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29224999
• Hazardous Substances Data: 305-03-3(Hazardous Substances Data)
• Toxicity: LD50 i.p. in rats: 58.2 mmole/kg (Ross)