Cephalothin sodium salt , 96% , 58-71-9

Synonym(s):
7-(2-Thienylacetamido)cephalosporanic acid sodium salt;Cephalothin sodium salt;Cephalotin sodium salt

CAS NO.：58-71-9

Empirical Formula: C16H16N2O6S2.Na

Molecular Weight: 418.42

MDL number: MFCD00072025

EINECS: 200-394-6

PRODUCT Properties

• Melting point: 240°C
• alpha: D +135° (c = 1.0 in water)
• storage temp.: Inert atmosphere,2-8°C
• solubility: H₂O: 50 mg/mL, clear, faintly yellow
• form: Solid
• color: White to Off-White
• Water Solubility: 158 mg/L
• Merck: 13,1994
• BRN: 4120706
• Stability: Hygroscopic

Description and Uses

Cefalothin is a β-lactam cephalosporin antibiotic. It inhibits the growth of various Gram-positive and Gram-negative bacteria, including several strains of S. pyogenes, S. aureus, C. tetani, N. gonorrhoeae, Salmonella, and Shigella (MICs = 0.1-0.2, 0.312-0.625, 0.078, 1.25, 1.56-6.25, and 3.12-12.5 μg/ml, respectively). Cefalothin binds to E. coli penicillin-binding proteins (PBPs; IC₅₀s = <0.25, 16, 37, and 1 μg/ml for PBP1a, 1bs, 2, and 3, respectively, in a radioligand binding assay), which interferes with bacterial morphogenesis. It exhibits antibacterial activity in mouse models of infection with S. pyogenes, D. pneumoniae, and S. aureus. Formulations containing cefalothin were previously used in the prophylaxis and treatment of bacterial infections.

Antibacterial;Bacterial transpeptidase inhibitor

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H317-H334
• Precautionary statements: P261-P280-P284-P304+P340-P342+P311
• Hazard Codes: Xn,Xi
• Risk Statements: 42/43
• Safety Statements: 22-36/37
• WGK Germany: 2
• RTECS: XI0388300
• HS Code: 29419000
• Toxicity: LD50 in mice, rats (mg/kg): >20000, >10000 orally; 5670, 7716 i.p. (Kuramoto)