Cefotaxime sodium salt , ≥99.5%（HPLC) , 64485-93-4

Synonym(s):
Cefotaxim sodium salt;Cefotaxime sodium salt

CAS NO.：64485-93-4

Empirical Formula: C16H16N5NaO7S2

Molecular Weight: 477.45

MDL number: MFCD00079073

EINECS: 264-915-9

PRODUCT Properties

• Melting point: 162-163 C
• alpha: D20 +55±2° (c = 0.8 in water)
• refractive index: 61 ° (C=1, H2O)
• storage temp.: Keep in dark place,Inert atmosphere,2-8°C
• solubility: H₂O: aqueous solutions of pH 4.3-6.2 are stable up to 3 weeks at 2-8 °C.soluble
• form: powder
• color: white to yellow
• PH: pH(100g/l, 25℃) : 4.5～6.5
• Water Solubility: Soluble in water.
• Merck: 14,1933
• BRN: 5711411
• Stability: Stable. Incompatible with strong oxidizing agents.

Description and Uses

Cefotaxime was synthesized by Hoechst and Roussel-Uclaf in 1977. It was the first derivative of cephalosporin to introduce the methoxyimino and aminothiazole groups at the 7 position of the cephem nucleus. Although it shows unexpectedly low oral absorption, its excellent activity against a wide range of gram-positive and gram-negative organisms, including Serratia, Enterobacter, Citrobacter, and anaerobes, guided research and development of the newer synthetic cephems, the so-called thirdgeneration cephalosporins.

Cefotaxime sodium salt acts as a beta-lactamase resistant antibiotic. It is used as an effective antibacterial against gram-negative bacteria, with the notable exception of pseudomonas and penicillin-resistant strains of streptococcus pneumoniae. It is used to treat infections of the bones, joints, skin, respiratory tract and blood stream.

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H317-H334
• Precautionary statements: P261-P280-P284-P304+P340-P333+P313-P342+P311
• Hazard Codes: Xn,Xi
• Risk Statements: 42/43
• Safety Statements: 22-36/37-60-45-37-24
• WGK Germany: 2
• RTECS: XI0250000
• HS Code: 29419000