Coenzyme A hydrate (free acid) , ≥85%(HPLC)

Synonym(s):
CoA;Coenzyme A (free acid)

CAS NO.：

Empirical Formula: C21H36N7O16P3S

Molecular Weight: 767.53

MDL number: MFCD06795839

EINECS: 201-619-0

PRODUCT Properties

• Density: 1.96±0.1 g/cm3(Predicted)
• storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• solubility: PBS (pH 7.2): 10 mg/ml
• form: A crystalline solid
• pka: 9.6 (thiol); pK 6.4 (secondary phosphate); pK 4.0 (adenine NH3+)
• color: White to light yellow
• Merck: 13,2491
• BRN: 77809
• InChIKey: RGJOEKWQDUBAIZ-IBOSZNHHSA-N
• SMILES: SCCNC(=O)CCNC(=O)[C@@H](C(COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](N2C3N=CN=C(N)C=3N=C2)[C@H](O)[C@@H]1OP(=O)(O)O)(C)C)O
• LogP: -4.358 (est)
• EPA Substance Registry System: Coenzyme A (85-61-0)

Description and Uses

Coenzyme A (CoA) is an essential cofactor functioning as an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. About 4% of cellular enzymes utilize CoA as a substrate. It is synthesized from pantothenic acid in a 5-step process that requires ATP. The pantothenate kinase step of the CoA biosynthetic pathway has been identified as a target for the development of antibacterial compounds.

Coenzyme A hydrate has been used in the thiolase enzyme assay of recombinant acetoacetyl-CoA thiolase (rACAT) in Clonorchis sinensis. It may be used as a reference standard in Raman spectra measurements.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H319-H315-H335
• Precautionary statements: P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
• Safety Statements: 24/25
• WGK Germany: 3
• F: 1-10
• TSCA: Yes
• HS Code: 2933299090