Coenzyme Q10 , 98% , 303-98-0

Synonym(s):
Coenzyme Q₁₀;Q-10;Ubiquinone 50;Ubiquinone-10

CAS NO.：303-98-0

Empirical Formula: C59H90O4

Molecular Weight: 863.34

MDL number: MFCD00042919

EINECS: 206-147-9

PRODUCT Properties

• Melting point: 49-51 °C
• Boiling point: 715.32°C (rough estimate)
• Density: 0.9145 (rough estimate)
• refractive index: 1.4760 (estimate)
• storage temp.: -20°C
• solubility: Soluble in chloroform.
• form: Solid
• color: Light Orange to Dark Orange
• Sensitive: Light Sensitive
• Merck: 14,9843
• BRN: 1900141
• Stability: Stable, but may be light or heat sensitive. Store in the dark at -20 C. Incompatible with strong oxidizing agents.
• InChIKey: ACTIUHUUMQJHFO-DQXDOXBUSA-N
• LogP: 19.119 (est)

Description and Uses

Coenzyme Q₁₀ (CoQ₁₀) is a quinone that is found throughout the human body in cell membranes, primarily in mitochondrial membranes, with the highest levels in the heart, lungs, liver, kidneys, spleen, pancreas, and adrenal glands. It exists in three redox states: fully oxidized (CoQ₁₀/ubiquinone), partially reduced (semiquinone or ubisemiquinone), and fully reduced (ubiquinol; ). CoQ₁₀ acts as an electron shuttle in the electron transport chain via its reduction to ubiquinol between mitochondrial complexes I and II, also known as NADH dehydrogenase and succinate dehydrogenase, respectively, and mitochondrial complex III, also known as cytochrome bc₁ complex. CoQ₁₀ is also reduced to ubiquinol by ferroptosis suppressor protein 1 (FSP1) with NADPH as a cofactor, and ubiquinol traps lipid peroxyl radicals and inhibits lipid peroxidation helping to prevent ferroptosis. Mutations in genes encoding enzymes involved in CoQ₁₀ biosynthesis lead to primary CoQ₁₀ deficiency, which is characterized by encephalopathy, cerebellar ataxia, infantile multisystemic form, nephropathy, and isolated myopathy. Secondary CoQ₁₀ deficiency, induced by non-genetic impaired CoQ₁₀ biosynthesis, insufficient CoQ₁₀ intake, or excessive CoQ₁₀ utilization, has been observed in a variety of conditions, including ataxia-oculomotor-apraxia 1 (AOA1), mitochondrial diseases, and hypercholesteremia with statin therapy. Formulations containing CoQ₁₀ have been used in the treatment of CoQ₁₀ deficiency.

Coenzyme Q10 (CoQ10) is a naturally occurring quinone found throughout the body in cell membranes, primarily in mitochondrial membranes, with highest concentrations in the heart, lungs, liver, kidneys, spleen, pancreas, and adrenal glands. It is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. In its reduced form, CoQ10 acts as an antioxidant, preventing the formation of reactive oxygen species. CoQ10 deficiencies have been associated with heart failure, hypertension, parkinsonism, mitochondrial encephalomyopathies, and other chronic diseases.[Cayman Chemical]

Safety

• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 22-24/25-26
• WGK Germany: 3
• RTECS: DK3900000
• F: 8-10
• TSCA: Yes
• HS Code: 29146990
• Toxicity: LD50 intramuscular in mouse: > 500mg/kg