Home Categories Organic Chemistry Mesityl oxide
A5388612

Mesityl oxide , StandardforGC,≥98%(GC) , 141-79-7

Synonym(s):
4-Methyl-3-penten-2-one;Isopropylideneacetone, 4-Methyl-3-penten-2-one;Mesityl oxide

CAS NO.:141-79-7

Empirical Formula: C6H10O

Molecular Weight: 98.14

MDL number: MFCD00008900

EINECS: 205-502-5

Update time: 2022-07-08

PRODUCT Properties

Melting point: −53 °C(lit.)
Boiling point: 129 °C(lit.)
Density  0.858 g/mL at 25 °C(lit.)
vapor pressure  10.5 hPa (20 °C)
refractive index  n20/D 1.442(lit.)
FEMA  3368 | 4-METHYL-3-PENTEN-2-ONE
Flash point: 87 °F
storage temp.  Store below +30°C.
solubility  30g/l
form  Liquid, Free Of Suspended Matter
color  Clear
Specific Gravity 0.86
Odor Strong; peppermint; honeylike.
explosive limit 1.4-10.1%(V)
Odor Type vegetable
Water Solubility  28 G/L (20 ºC)
Merck  14,5908
JECFA Number 1131
BRN  1361550
Henry's Law Constant (x 10-6 atm?m3/mol): 4.01 at 20 °C (approximate - calculated from water solubility and vapor pressure)
Exposure limits TLV-TWA 60 mg/m3 (15 ppm) (ACGIH), 10-h TWA 40 mg/m3 (10 ppm) (NIOSH); STEL 100 mg/m3 (25 ppm); IDLH 5000 ppm.
Dielectric constant 15.4(20℃)
Stability: Light Sensitive
LogP 1.37 at 20℃

Description and Uses

The commercial grade of 4-methyl-3-penten-2-one exhibits an unpleasant grassy-green or pungent, acrylic odor. The pure material has a pleasant, honey-like odor. This substance may be prepared by reacting acetone or diacetone alcohol with iodine or other dehydrating agent; by condensation of acetone over sulfonated polystyrene-divinylbenzene resin used as an ion exchange catalyst.

4-Methyl-4-penten-2-one is used to a small extent as an intermediate in synthesis. Most of it is converted to 4-methyl-2-pentanone by selective hydrogenation. Although 4-methyl-2- pentanone has excellent solvent properties for nitrocellulose, cellulose esters and ethers, copolymers of vinyl chloride – vinyl acetate and other synthetic resins, as well as natural and synthetic rubber, its use as a solvent is limited as a result of its toxicity and chemical instability. The fraction of 4-methyl-4-penten-2-one permitted in solvent systems has been set at 5 vol% (Rule 66 of the Los Angeles, California, Air Pollution Control District). Some of the numerous possible reactions that mesityl oxide may undergo have been used for the synthesis of products such as Budralazine, an antihypertensive agent.

Safety

Symbol(GHS) 
GHS02,GHS06
Signal word  Danger
Hazard statements  H226-H302+H312-H315-H319-H331-H335
Precautionary statements  P210-P280-P301+P312-P303+P361+P353-P304+P340+P311-P305+P351+P338
Hazard Codes  Xn
Risk Statements  10-20/21/22-36/37/38
Safety Statements  25
RIDADR  UN 1229 3/PG 3
OEB A
OEL TWA: 10 ppm (40 mg/m3)
WGK Germany  1
RTECS  SB4200000
Autoignition Temperature 344 °C
TSCA  Yes
HS Code  2914 19 90
HazardClass  3
PackingGroup  III
Toxicity LD50 in mice (mg/kg): 710 ±85 intragastric; LC50 in mice (2 hr), rats (4 hr) (mg/m3): 10000 ±270, 9000 ±600 (Ismerov)
IDLA 1,400 ppm [10% LEL]

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