Cleviprex , ≥99% , 167221-71-8
CAS NO.：167221-71-8
Empirical Formula: C21H23Cl2NO6
Molecular Weight: 456.32
MDL number: MFCD00940070
EINECS: 682-702-2
| Pack Size | Price | Stock | Quantity |
| 25MG | RMB47.20 | In Stock |
|
| 100MG | RMB127.20 | In Stock |
|
| 500MG | RMB484.80 | In Stock |
|
| 1G | RMB752.80 | In Stock |
|
| 5G | RMB1522.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 128-130°C |
| Boiling point: | 539.7±50.0 °C(Predicted) |
| Density | 1.289 |
| Flash point: | 280℃ |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Insoluble[in water] |
| Water Solubility | Insoluble in water |
| solubility | ≥21.4 mg/mL in DMSO; insoluble in H2O; ≥7.45 mg/mL in EtOH with ultrasonic |
| form | powder to crystal |
| pka | 2.45±0.70(Predicted) |
| color | White to Light yellow |
| CAS DataBase Reference | 167221-71-8 |
Description and Uses
Clevidipine is an ultra-short-acting vasodilator of the dihydropyridine
(DHP) class of CCB. It is indicated as an intravenous treatment for the
acute management of hypertension when oral therapy is not feasible or
not desirable. Clevidipine is the second intravenous CCB to be marketed
behind nicardipine for this indication. Both agents are primarily used
for urgent treatment of hypertension in cardiac surgical setting, intensive
care units, and emergency departments. Other intravenous agents
currently on the market for this indication include sodium nitroprusside,
nitroglycerin, fenoldopam, hydralazine, esmolol, and labetalol. Clevidipine is a potent, arterial-specific, vasodilator with very little or no effect
on the myocardial contractility and venous capacitance. It has a
rapid onset and offset of action and a very short plasma half-life, which
allows for titration of the drug to achieve precise BP control.
clevidipine is exclusively metabolized in the blood and the tissues. It does not undergo any renal or hepatic metabolism and does not accumulate in the body. Clevidipine is a blocker of L-type calcium channels, which mediate the influx of calcium during depolarization in arterial smooth muscle.
Clevidipine butyrate is a dihydropyridine calcium channel blocker use as agent for the reduction of blood pressure。
Safety
| Symbol(GHS) |  GHS08 |
| Signal word | Warning |
| Hazard statements | H361 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501 |
| Safety Statements | 24/25 |
| HS Code | 29339900 |
