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S9554448

clone3F6.5,frommouse

Synonym(s):
(S)-3-(Aminomethyl)-5-methylhexanoic acid;(S)-3-(Aminomethyl)-5-methylhexanoic acid; (S)-3-Isobutyl-γ-aminobutyric acid;3-Isobutyl GABA;,

CAS NO.:

Empirical Formula: C8H17NO2

Molecular Weight: 159.23

MDL number: MFCD00917044

EINECS: 604-639-1

Pack Size Price Stock Quantity
100μG RMB3676.66 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 194-196°C
alpha  D23 +10.52° (c = 1.06 in water)
Boiling point: 274.0±23.0 °C(Predicted)
Density  0.997±0.06 g/cm3(Predicted)
Flash point: 9℃
storage temp.  2-8°C
solubility  deionized water: ≥10mg/mL
pka 4.23±0.10(Predicted)
form  white powder
Water Solubility  Soluble to 100 mM in water
BCS Class 1
InChI InChI=1S/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m0/s1
InChIKey AYXYPKUFHZROOJ-ZETCQYMHSA-N
SMILES C(O)(=O)C[C@@H](CN)CC(C)C

Description and Uses

Pregabalin (Lyrica), a derivative of GABA that is closely related to gabapentin, has undergone extensive research for its efficacy in treating conditions such as generalized anxiety disorder (GAD), fibromyalgia, neuropathic pain, and partial complex seizures. It seems to have a more targeted effect on the a2-δ subunit of calcium channels in the brain compared to gabapentin. Pregabalin was granted FDA approval at the end of 2004 for the treatment of neuropathic pain and epilepsy. In 2008, it became the first medication approved for the management of fibromyalgia. Although pregabalin was approved for GAD treatment in the European Union in 2006, it has not yet received FDA approval for GAD in the United States as of the time of writing.

Pregabalin is an anticonvulsant drug used for neuropathic pain, as an adjunct therapy for partial seizures, and in generalized anxiety disorder. It was designed as a more potent successor to gabapentin. Pregabalin is marketed by Pfizer under the trade nam

Safety

Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H336-H361
Precautionary statements  P201-P202-P261-P271-P280-P308+P313
Hazard Codes  Xn,T,F
Risk Statements  63-48/22-39/23/24/25-23/24/25-11
Safety Statements  22-36/37-45-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
HS Code  29224999

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