Home Categories Natural Products Catalpol
A2341612

Catalpol , ≥97%(HPLC) , 2415-24-9

Synonym(s):
(1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-Hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl-β-D-glucopyranoside;Catalpinoside;De(p-hydroxybenzoyl)catalposide

CAS NO.:2415-24-9

Empirical Formula: C15H22O10

Molecular Weight: 362.33

MDL number: MFCD11111524

EINECS: 219-324-0

Pack Size Price Stock Quantity
100MG RMB446.40 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 203-205°C
Boiling point: 675.6±55.0 °C(Predicted)
Density  1.72±0.1 g/cm3(Predicted)
storage temp.  Inert atmosphere,Store in freezer, under -20°C
solubility  DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
form  Solid
pka 12.79±0.70(Predicted)
color  White to Off-White
InChIKey LHDWRKICQLTVDL-CLLMHHLUSA-N
LogP -4.609 (est)

Description and Uses

Catalpol is an iridoid glycoside that has been isolated from R. glutinosa and has diverse biological activities, including anti-apoptotic, pro-angiogenic, and radioprotective properties. It protects against mitochondrial pathway-dependent apoptosis in PC12 rat adrenal pheochromocytoma cells and H9c2 rat embryonic ventricular myocardial cells when used at a concentration of 10 μM. Catalpol pretreatment reduces apoptosis and improves viability in AHH-1 human lymphocyte cells exposed to ionizing radiation and reduces intestinal damage induced by radiation in mice when used at concentrations and doses ranging from of 25 to 100 μg/ml and 25 to 100 mg/kg, respectively. In a rat model of stroke, catalpol (5 mg/kg, i.p.) increases the expression of erythropoietin and VEGF and improves angiogenesis in the brain.

Catapol is an iridoid glucoside that has been shown to alleviate neuropathic pain.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  LZ5776816
HS Code  29389090
Toxicity mouse,LD,intravenous,> 2500mg/kg (2500mg/kg),Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64, Pg. 93, 1968.

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