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A0674112

Artemisinin , 98% , 63968-64-9

Synonym(s):
Arteannuin;Qinghaosu

CAS NO.:63968-64-9

Empirical Formula: C15H22O5

Molecular Weight: 282.33

MDL number: MFCD00081057

EINECS: 1806241-263-5

Pack Size Price Stock Quantity
1G RMB27.20 In Stock
5G RMB83.20 In Stock
25G RMB316.80 In Stock
100G RMB923.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 156-157 °C (lit.)
alpha  76 º (c=0.5,MeOH)
Boiling point: 344.94°C (rough estimate)
Density  1.0984 (rough estimate)
refractive index  75 ° (C=0.5, MeOH)
storage temp.  -20°C
solubility  Soluble to 100mM in DMSO and to 75mM in ethanol
form  White to off-white crystalline solid.
color  Needles
optical activity [α]20/D +76°, c = 0.5 in methanol
Merck  14,817
Stability: Stable. Combustible. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides. May absorb, and react with, carbon dioxide from the air.
InChI InChI=1S/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14-,15-/m1/s1
InChIKey BLUAFEHZUWYNDE-NNWCWBAJSA-N
SMILES O1[C@]23[C@@]4([H])O[C@@](C)(CC[C@@]2([H])[C@H](C)CC[C@@]3([H])[C@@H](C)C(=O)O4)O1
LogP 2.900

Description and Uses

Artemisinin is an antimalarial agent with anticancer activity. It is an iron(II) oxide-reactive endoperoxide that generates reactive oxygen species (ROS) upon cleavage of its endoperoxide bridge. It reduces the growth of various P. falciparum strains in vitro (IC50s = 3.98-20.36 nM) and reduces parasitemia in mice infected with P. falciparum with a curative dose (CD50) value of 140 mg/kg. It also reduces P. berghei infection in mice (ED50 = 5.6 mg/kg per day). Artemisinin (100-400 μM) induces cell cycle arrest in the G0/G1 phase and apoptosis and inhibits growth of SK-N-AS, BE(2)-C, SK-N-DZ, and SHEP1 neuroblastoma cells in a time- and concentration-dependent manner. It also suppresses BE(2)-C cell colony formation in a soft agar assay and reduces tumor growth in a BE(2)-C mouse xenograft model. Formulations containing artemisinin have been used in combination therapies for the treatment of malaria.

An antimalarial agent that inhibits VEGF expression and NOS2.

Safety

Symbol(GHS) 
GHS02,GHS09
Signal word  Warning
Hazard statements  H242-H400-H410
Precautionary statements  P210-P220-P234-P280-P280-P273-P391-P420-P410
Safety Statements  22-24/25
WGK Germany  2
RTECS  KD4170000
HS Code  29322985
Toxicity LD50 in mice (mg/kg): 5105 orally; 2800 i.m.; 1558 i.p. (Koch); LD50 in mice, rats (mg/kg): 4228, 5576 orally; 3840, 2571 i.m. (China Cooperative Research Group on Qinghaosu)

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