Colchicine , Analysis of standard products, ≥99%(HPLC) , 64-86-8

Synonym(s):
(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide;Colchicine;Colchicine, Colchicum autumnale - CAS 64-86-8 - Calbiochem

CAS NO.：64-86-8

Empirical Formula: C22H25NO6

Molecular Weight: 399.44

MDL number: MFCD00078484

EINECS: 200-598-5

PRODUCT Properties

• Melting point: 150-160 °C (dec.)(lit.)
• alpha: -250 º (c=1, alcohol)
• Boiling point: 522.37°C (rough estimate)
• Density: 1.2770 (rough estimate)
• refractive index: 1.5614 (estimate)
• storage temp.: 2-8°C
• solubility: H₂O: 10 mg/mL
• pka: 12.36(at 20℃)
• form: powder
• color: white to yellow with a green cast
• Water Solubility: 45 g/L (20 ºC)
• Sensitive: Light Sensitive
• Merck: 14,2471
• BRN: 2228813
• BCS Class: 3
• Stability: Stable. Light sensitive. Incompatible with strong oxidizing agents.
• InChIKey: IAKHMKGGTNLKSZ-INIZCTEOSA-N
• LogP: 1.300

Description and Uses

Colchicine is a pale-yellow powder that is obtained from various species of Colchicum, primarily Colchicum autumnale L. Its total chemical synthesis has been achieved, but the primary source of colchicine currently remains alcohol extraction of the alkaloid from the corm and seed of C. autumnale L. It darkens on exposure to light and possesses

anti-inflammatory agent, mitosis inhibitor

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H300-H340
• Precautionary statements: P202-P264-P270-P280-P301+P310-P405
• Hazard Codes: T+,T,Xi
• Risk Statements: 26/28-41-46
• Safety Statements: 13-45-36/37/39-28-26-53
• RIDADR: UN 1544 6.1/PG 1
• WGK Germany: 3
• RTECS: GH0700000
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: I
• HS Code: 29399990
• Toxicity: LD50 in rats (mg/kg): 1.6 i.v. (Rosenbloom, Ferguson); in mice (mg/kg): 4.13 i.v. (Beliles)