Artemisinin , Analysis standard , 63968-64-9
Synonym(s):
Arteannuin;Qinghaosu
CAS NO.：63968-64-9
Empirical Formula: C15H22O5
Molecular Weight: 282.33
MDL number: MFCD00081057
EINECS: 1806241-263-5
| Pack Size | Price | Stock | Quantity |
| 20MG | RMB55.20 | In Stock |
|
| 100mg | RMB239.20 | In Stock |
|
| 500mg | RMB367.20 | In Stock |
|
| 1g | RMB559.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 156-157 °C (lit.) |
| alpha | 76 º (c=0.5,MeOH) |
| Boiling point: | 344.94°C (rough estimate) |
| Density | 1.0984 (rough estimate) |
| refractive index | 75 ° (C=0.5, MeOH) |
| storage temp. | -20°C |
| solubility | Soluble to 100mM in DMSO and to 75mM in ethanol |
| form | White to off-white crystalline solid. |
| color | Needles |
| optical activity | [α]20/D +76°, c = 0.5 in methanol |
| Merck | 14,817 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides. May absorb, and react with, carbon dioxide from the air. |
| InChI | InChI=1S/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14-,15-/m1/s1 |
| InChIKey | BLUAFEHZUWYNDE-NNWCWBAJSA-N |
| SMILES | O1[C@]23[C@@]4([H])O[C@@](C)(CC[C@@]2([H])[C@H](C)CC[C@@]3([H])[C@@H](C)C(=O)O4)O1 |
| LogP | 2.900 |
Description and Uses
Artemisinin is an antimalarial agent with anticancer activity. It is an iron(II) oxide-reactive endoperoxide that generates reactive oxygen species (ROS) upon cleavage of its endoperoxide bridge. It reduces the growth of various P. falciparum strains in vitro (IC50s = 3.98-20.36 nM) and reduces parasitemia in mice infected with P. falciparum with a curative dose (CD50) value of 140 mg/kg. It also reduces P. berghei infection in mice (ED50 = 5.6 mg/kg per day). Artemisinin (100-400 μM) induces cell cycle arrest in the G0/G1 phase and apoptosis and inhibits growth of SK-N-AS, BE(2)-C, SK-N-DZ, and SHEP1 neuroblastoma cells in a time- and concentration-dependent manner. It also suppresses BE(2)-C cell colony formation in a soft agar assay and reduces tumor growth in a BE(2)-C mouse xenograft model. Formulations containing artemisinin have been used in combination therapies for the treatment of malaria.
An antimalarial agent that inhibits VEGF expression and NOS2.
Safety
| Symbol(GHS) |   GHS02,GHS09 |
| Signal word | Warning |
| Hazard statements | H242-H400-H410 |
| Precautionary statements | P210-P220-P234-P280-P280-P273-P391-P420-P410 |
| Safety Statements | 22-24/25 |
| WGK Germany | 2 |
| RTECS | KD4170000 |
| HS Code | 29322985 |
| Toxicity | LD50 in mice (mg/kg): 5105 orally; 2800 i.m.; 1558 i.p. (Koch); LD50 in mice, rats (mg/kg): 4228, 5576 orally; 3840, 2571 i.m. (China Cooperative Research Group on Qinghaosu) |
