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A2316012

Celastrol , 98% , 34157-83-0

Synonym(s):
10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid;Celastrol, Celastrus scandens - CAS 34157-83-0 - Calbiochem;Tripterin;Tripterin, 3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic Acid, Proteasome Inhibitor XIX

CAS NO.:34157-83-0

Empirical Formula: C29H38O4

Molecular Weight: 450.61

MDL number: MFCD03424073

EINECS: 636-472-5

Pack Size Price Stock Quantity
10MG RMB194.40 In Stock
50MG RMB718.40 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 219-230°C
Boiling point: 645.7±55.0 °C(Predicted)
Density  1.2
storage temp.  -20°C
solubility  DMSO: >10mg/mL
pka 4.78±0.70(Predicted)
form  solid
color  red
λmax 424nm(MeOH)(lit.)
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChIKey KQJSQWZMSAGSHN-JJWQIEBTSA-N
LogP 7.080 (est)

Description and Uses

Celastrol (34157-83-0) displays potent antioxidant and anti-inflammatory activity. Inhibits NFkB (IC50=270 nM). ?It induces heat shock response and cytoprotection in various cells. Inhibits 20S proteasome chymotrypsin activity (IC50=2.5 mM). Induces autophagy by targeting AR/miR-101 in prostate cancer cells.4 Induces UPR-dependent cell death in cancer cells.5 Cell permeable.

Celastrol is an antioxidant natural product which inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Used for clinical treatment for rheumatoid arthritis, was demonstrated to have antiangiogenic activity, and be inhibitory against mice tumor growth by a few recent studies. Celastrol also has been shown to have the power to kill tumor cells and can work as an anticarcinogen. It is also a leptin sensitizer with the potential to reduce weight in obesity.

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  45-24/25
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  2
RTECS  YJ7900000
HS Code  29189900

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