Celastrol , 98% , 34157-83-0
Synonym(s):
10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid;Celastrol, Celastrus scandens - CAS 34157-83-0 - Calbiochem;Tripterin;Tripterin, 3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic Acid, Proteasome Inhibitor XIX
CAS NO.：34157-83-0
Empirical Formula: C29H38O4
Molecular Weight: 450.61
MDL number: MFCD03424073
EINECS: 636-472-5
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB194.40 | In Stock |
|
| 50MG | RMB718.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 219-230°C |
| Boiling point: | 645.7±55.0 °C(Predicted) |
| Density | 1.2 |
| storage temp. | -20°C |
| solubility | DMSO: >10mg/mL |
| pka | 4.78±0.70(Predicted) |
| form | solid |
| color | red |
| λmax | 424nm(MeOH)(lit.) |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| InChIKey | KQJSQWZMSAGSHN-JJWQIEBTSA-N |
| LogP | 7.080 (est) |
Description and Uses
Celastrol (34157-83-0) displays potent antioxidant and anti-inflammatory activity. Inhibits NFkB (IC50=270 nM). ?It induces heat shock response and cytoprotection in various cells. Inhibits 20S proteasome chymotrypsin activity (IC50=2.5 mM). Induces autophagy by targeting AR/miR-101 in prostate cancer cells.4 Induces UPR-dependent cell death in cancer cells.5 Cell permeable.
Celastrol is an antioxidant natural product which inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Used for clinical treatment for rheumatoid arthritis, was demonstrated to have antiangiogenic activity, and be inhibitory against mice tumor growth by a few recent studies. Celastrol also has been shown to have the power to kill tumor cells and can work as an anticarcinogen. It is also a leptin sensitizer with the potential to reduce weight in obesity.
