Myricetin , Analysis of standard products, ≥98% , 529-44-2

Synonym(s):
3,3ʹ,4ʹ,5,5ʹ,7-Hexahydroxyflavone, Hsp70 Inhibitor II;3,3′,4′,5,5′,7-Hexahydroxyflavone;Cannabiscetin;Myricetin - CAS 529-44-2 - Calbiochem;Myricetol

CAS NO.：529-44-2

Empirical Formula: C15H10O8

Molecular Weight: 318.24

MDL number: MFCD00006827

EINECS: 208-463-2

PRODUCT Properties

• Melting point: >300 °C(lit.)
• Boiling point: 377.41°C (rough estimate)
• Density: 1.4222 (rough estimate)
• refractive index: 1.4395 (estimate)
• storage temp.: 2-8°C
• solubility: ethanol: soluble10mg/mL, clear to very faintly turbid, yellow to very deep greenish-yellow
• pka: 6.30±0.40(Predicted)
• form: crystalline
• color: Yellowish Brown
• Water Solubility: Soluble in dimethyl sulfoxide,dimethyl formamide and ethanol. Insoluble in water.
• Merck: 14,6332
• BRN: 332331
• Stability: Hygroscopic
• InChIKey: IKMDFBPHZNJCSN-UHFFFAOYSA-N
• LogP: 1.206 (est)

Description and Uses

Myricetin[529-44-2] is a flavonoid compound found in many fruits and vegetables, including red wine, that acts as a powerful antioxidant. Myricetin inhibits TBARS formation with an IC₅₀ value of 6.34 and at 20 μM, blocks oxLDL uptake by U937-derived macrophages, reducing CD36 expression. Myricetin demonstrates potent chemopreventative potential by binding JAK1/STAT3 to inhibit the neoplastic transformation of murine JB6 P+ cells and inhibiting MEK1 kinase activity.

Myricetin is used as an antioxidant. It is a cell-permeable flavonoid used in inflammatory, diabetes, and cancer studies. It is effective in protecting neurons against oxidative stresses. Further, it inhibits yeast alfa-glucosidase,1 glyoxalase I in vitro and bovine milk xanthine oxidase.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: LK8646000
• F: 10
• HS Code: 29329990