Home Categories Pharmaceutical intermediates 4-(Chloromethyl)pyridine hydrochloride
A2312912

4-(Chloromethyl)pyridine hydrochloride , 97% , 1822-51-1

Synonym(s):
4-Picolyl chloride hydrochloride

CAS NO.:1822-51-1

Empirical Formula: C6H7Cl2N

Molecular Weight: 164.03

MDL number: MFCD00012826

EINECS: 217-350-7

Pack Size Price Stock Quantity
5G RMB25.60 In Stock
25G RMB43.20 In Stock
100G RMB168.80 In Stock
500g RMB702.40 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 166-173 °C(lit.)
storage temp.  Inert atmosphere,2-8°C
solubility  soluble in DMSO, Methanol
form  Fine Crystalline Powder
color  Yellow to orange
Water Solubility  750 g/L (20 ºC)
Sensitive  Hygroscopic
BRN  3689154

Description and Uses

It finds its application as a reagent for protection of carboxyl termini of peptides as 4-picolyl esters, providing a polar 'handle' which aids in separation and purification of the peptide. The group can be introduced in the presence of a base, e.g. tetramethylguanidine, is stable to acid-catalyzed removal of Cbz protecting group and can be removed by base, Na in liquid ammonia or catalytic hydrogenolysis. It is also applied in conjunction with Amberlyst?15 resin in peptide synthesis. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

Safety

Symbol(GHS) 
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363
Hazard Codes  C,Xi
Risk Statements  34-4-22-36/37/38
Safety Statements  26-36/37/39-45-36
RIDADR  UN 3261 8/PG 3
WGK Germany  3
3-10
Hazard Note  Corrosive
HazardClass  8
PackingGroup  III
HS Code  29333999

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