Choline chloride , AR,98% , 67-48-1

Synonym(s):
(2-Hydroxyethyl)trimethylammonium chloride

CAS NO.：67-48-1

Empirical Formula: C5H14ClNO

Molecular Weight: 139.62

MDL number: MFCD00011721

EINECS: 200-655-4

PRODUCT Properties

• Melting point: 302-305 °C (dec.) (lit.)
• Density: 1.0238 (rough estimate)
• refractive index: 1.5400 (estimate)
• FEMA: 4500 | Choline chloride (Also Includes Choline)
• storage temp.: Sealed in dry,Room Temperature
• solubility: H₂O: 1 M, clear, colorless
• form: Adhering Crystals
• color: White
• PH: 5.0-7.5 (25℃, 1M in H2O)
• Odor: sl. odor of trimethylamine
• Water Solubility: soluble
• Sensitive: Hygroscopic
• λmax: λ: 260 nm Amax: 0.015; λ: 280 nm Amax: 0.010
• JECFA Number: 2003
• Merck: 14,2206
• BRN: 3563126
• Stability: Stable. Incompatible with strong oxidizing agents, moisture. Store under a dry atmosphere.
• InChIKey: SGMZJAMFUVOLNK-UHFFFAOYSA-M
• LogP: -3.70
• CAS DataBase Reference: 67-48-1(CAS DataBase Reference)
• NIST Chemistry Reference: Choline chloride(67-48-1)
• EPA Substance Registry System: Choline chloride (67-48-1)

Description and Uses

Choline chloride is an animal feed additive, classified as a water-soluble B-vitamin that increases animal growth. ChCl is added exogenously to feedstocks because it plays an essential role in fat transport and metabolism and protects cell membrane structure. It can be supplied to tissue culture media and animal feed additives and used as a clinical anti-fatty liver agent.
It can be used to treat fatty liver and cirrhosis. It can also be used as a feed additive, stimulating the ovaries to give birth to more eggs and farrow. It can also facilitate the weight-gaining process of livestock, fish, etc.
Choline chloride is effective in preventing and treating fat deposition and tissue degeneration in livestock and poultry organs. It can also promote the absorption and synthesis of amino acids. Moreover, it can enhance livestock's physical fitness and disease resistance, promote their growth and development, and improve poultry laying rate. The usage amount is 1-2 g/kg.
As a kind of feed additive, choline chloride has the following physiological effects: it can prevent the accumulation of fat in the liver and the kidney and tissue degeneration; it can promote the recombination of amino acids; it can improve the utilization efficiency of amino acids, especially the essential amino acid methionine in vivo. In Japan, 98% of the applied choline chloride is used as feed additives for chickens, pigs, cattle, fish, and other animals. Most of them have been processed into powder; the preparation process of 50% powder is that: first, add an appropriate excipient of specific particle size into the mixer prepared by previously adding an appropriate particle size of the excipient, and then add dropwise of aqueous solution of choline chloride, after mixing, drying to derive it. Some powder products are also blended with vitamins, minerals, and drugs. Choline chloride is a vitamin B-class drug that can be used for the treatment of hepatitis, liver function degradation, early cirrhosis, and pernicious anemia.
It is a precursor of acetylcholine and is a methyl donor in various metabolic processes and lipid metabolism.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H303-H335
• Precautionary statements: P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 1
• RTECS: KH2975000
• F: 3-9
• TSCA: Yes
• HS Code: 29212900
• Hazardous Substances Data: 67-48-1(Hazardous Substances Data)
• Toxicity: LD50 in rats (g/kg): 0.400 i.p.; 6.64 orally (Hartung, Cornish)