Home Categories Biochemical Engineering L-Carnosine
A2310612

L-Carnosine , 98% , 305-84-0

Synonym(s):
β-Alanyl-L-histidine

CAS NO.:305-84-0

Empirical Formula: C9H14N4O3

Molecular Weight: 226.23

MDL number: MFCD00005207

EINECS: 206-169-9

Pack Size Price Stock Quantity
1G RMB37.60 In Stock
5G RMB75.20 In Stock
25G RMB184.00 In Stock
100G RMB716.80 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 253 °C (dec.) (lit.)
alpha  20.9 º (c=1.5, H2O)
Boiling point: 367.84°C (rough estimate)
Density  1.2673 (rough estimate)
vapor pressure  0Pa at 25℃
refractive index  21 ° (C=2, H2O)
storage temp.  -20°C
solubility  DMSO (Very Slightly), Water (Slightly)
form  crystalline
pka 2.62(at 25℃)
color  White
Odor at 100.00?%. odorless
optical activity +24.120
Water Solubility  almost transparency
Merck  14,1850
BRN  87671
Stability: Stable, but may be heat sensitive - store cold. Incompatible with strong oxidizing agents.
InChIKey CQOVPNPJLQNMDC-ZETCQYMHSA-N
LogP -3.8 at 22℃

Description and Uses

L-Carnosine is a dipeptide composed of β-alanine and L-histidine that has been found in rat olfactory bulb, skeletal muscle, brain, kidney, and spleen tissues, as well as human skeletal muscle, and has diverse biological activities. It is a metal chelator that forms complexes with copper, cobalt, nickel, cadmium, or zinc. Dietary administration of L-carnosine (60 mg/kg per day) reduces plasma levels of advanced glycation end products (AGEs) in diabetic rats. It reduces brain edema, blood-brain barrier disruption, microglial activation, and neuronal apoptosis in a rat model of intracerebral hemorrhage when administered at a dose of 1,000 mg/kg. L-Carnosine (250, 500, and 1,000 mg/kg, i.p.) reduces hepatic protein carbonylation and necrosis in a rat model of cirrhosis induced by bile duct ligation. It also reduces lung myeloperoxidase (MPO) activity, production of reactive oxygen species (ROS), and TNF-α and IL-6 levels, as well as alveolar hemorrhage, interstitial edema, and pulmonary leukocyte infiltration in a mouse model of LPS-induced lung injury.

L-Carnosine is a naturally-occurring histidine-containing compound and the biological role of this dipeptide is to act as cytosolic buffering agents. Other roles ascribed to L-Carnosine include action s as neurotransmitters, modulation of enzymic activities and chelation of heavy metals. Studies indicate an ability to boost the immunological functions. In cosmetics, it has anti-aging and skin-conditioning applications.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  24/25-36-26
WGK Germany  2
RTECS  MS3080000
3-10
TSCA  Yes
HS Code  29332900
Toxicity LD50 oral in mouse: > 14930mg/kg

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