L-Histidine , EP, USP, non -animal source, for cell culture , 71-00-1

Synonym(s):
HIS;(S)-2-Amino-3-(4-imidazolyl)propionic acid;AKR1B11;Aldo-keto reductase family member B10;ALDRLn

CAS NO.：71-00-1

Empirical Formula: C6H9N3O2

Molecular Weight: 155.15

MDL number: MFCD00064315

EINECS: 200-745-3

PRODUCT Properties

• Melting point: 282 °C (dec.)(lit.)
• alpha: 12.4 º (c=11,6N HCl)
• Boiling point: 278.95°C (rough estimate)
• Density: 1.3092 (rough estimate)
• FEMA: 3694 | L-HISTIDINE
• refractive index: 13 ° (C=11, 6mol/L HCl)
• storage temp.: 2-8°C
• solubility: H₂O: 50 mg/mL
• form: powder
• pka: 1.8(at 25℃)
• color: White to off-white or pale yellow
• PH Range: 7 - 8 at 15.5 g/l at 25 °C
• PH: 7.0-8.0 (25℃, 0.1M in H2O)
• Odor: odorless
• Odor Type: odorless
• optical activity: [α]20/D 39±1°, c = 2% in H2O
• Water Solubility: 41.6 g/L (25 ºC)
• λmax: λ: 260 nm Amax: 0.05; λ: 280 nm Amax: 0.05
• JECFA Number: 1431
• Merck: 14,4720
• BRN: 4673585
• Stability: Stable. Incompatible with strong oxidizing agents.
• InChIKey: HNDVDQJCIGZPNO-YFKPBYRVSA-N
• LogP: -1.27

Description and Uses

White, odorless crystals or crystalline powder having a slightly bitter taste. It is soluble in water, very slightly soluble in alcohol, and insoluble in ether. It melts with decomposition between about 277° and 288°C.

L-Histidine acts as a precursor to histamine and a component of carnosine. It is also used in medicine, feed additive, biochemical research, dietary supplement. It is used in a nutrition enhancer, is the amino acid fluid infusion. It can be used in the treatment of gastric ulcer.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P280-P301+P312-P302+P352-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38
• Safety Statements: 24/25-36/37-26-22
• WGK Germany: 2
• RTECS: MS3070000
• F: 10-23
• TSCA: Yes
• HS Code: 29332990
• Toxicity: LD50 orally in Rabbit: > 5110 mg/kg