Bethanechol Chloride , >98.0%(T) , 590-63-6
Synonym(s):
Bethanechol chloride;Carbamyl-β-methylcholine chloride;Carbamyl-β-methylcholine chloride, Muscarinic Acetylcholine Receptors (mAChR) Agonist, Bethanechol Chloride
CAS NO.：590-63-6
Empirical Formula: C7H17ClN2O2
Molecular Weight: 196.68
MDL number: MFCD00055224
EINECS: 209-686-8
| Pack Size | Price | Stock | Quantity |
| 5G | RMB302.40 | In Stock |
|
| 25G | RMB986.40 | In Stock |
|
| 100G | RMB2774.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 187-190°C |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | H2O: 1.7 g/mL stable for several days at 4°C. |
| form | crystalline |
| color | white |
| Merck | 14,1185 |
Description and Uses
Bethanechol is an agonist of muscarinic acetylcholine receptors with IC50 values of 1,837, 25, 631, 317, and 393 μM for M1-5, respectively, in a radioligand binding assay using CHO cells expressing the human receptors. It inhibits M2-mediated increases in cyclic AMP induced by isoproterenol in isolated guinea pig small intestine (IC50 = 127 μM). Bethanechol increases basal tone of isolated porcine intravesical ureter (EC50 = 4.27 μM). It also induces fluid secretion in the ileum, duodenum, and jejunum of anesthetized rats when administered at a dose of 60 μg/kg. Formulations containing bethanechol have been used to increase urination and improve smooth muscle tone in the gastrointestinal tract.
Therapeutic action of Betanechol is based on this action, and it is used for treating postoperational non-obstructive retention of urine and neurogenic bladder atony. Earlier, it was used for treating gastrointestinal illnesses and Alzheimer’s disease.
