Brinzolamide , ≥98% , 138890-62-7
Synonym(s):
(5R)-5-Ethylamino-3-(3-methoxypropyl)-2,2-dioxo-2?6,9-dithia-3-azabicyclo[4.3.0]nona-7,10-diene-8-sulfonamide;(R)- 4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide;AL 4862
CAS NO.：138890-62-7
Empirical Formula: C12H21N3O5S3
Molecular Weight: 383.51
MDL number: MFCD08067749
EINECS: 620-511-8
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB26.40 | In Stock |
|
| 50MG | RMB116.00 | In Stock |
|
| 100MG | RMB222.40 | In Stock |
|
| 250mg | RMB223.20 | In Stock |
|
| 1G | RMB431.20 | In Stock |
|
| 5G | RMB1574.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 130.0 to 134.0 °C |
| Boiling point: | 586.0±60.0 °C(Predicted) |
| Density | 1.50±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: ≥10mg/mL |
| form | powder |
| pka | 9.62±0.40(Predicted) |
| color | white to beige |
| Merck | 14,1376 |
| InChIKey | HCRKCZRJWPKOAR-JTQLQIEISA-N |
Description and Uses
Brinzolamide is a carbonic anhydrase inhibitor developed by Alcon (now Novartis) as a treatment for primary and open-angle glaucoma and ocular hypertension. It was First approval in the United States in 1998 under the trade name Azopt. It is the second of this class after dorzolamide (1995). Brinzolamide was approved as a generic medication in the United States in November 2020.Brinzolamide is a white powder commercially formulated as a 1% ophthalmic suspension to reduce intraocular pressure (IOP). In patients with primary open-angle glaucoma or ocular hypertension, brinzolamide produced significant reductions in IOP and showed less ocular discomfort than dorzolamide.
Brinzolamide is a sulfonamide and carbonic anhydrase inhibitor with specific affinity for carbonic anhydrase II. Following topical ocular administration, brinzolamide inhibits carbonic anhydrase II, an enzyme that is responsible for the movement of sodium and fluid transport in the eye. This inhibition leads to a decrease in aqueous humor secretion, probably by slowing the formation of bicarbonate ions, and results in a reduction in intraocular pressure. Brinzolamide is used to treat increased pressure in the eye caused by open-angle glaucoma.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312+P330-P501 |
| WGK Germany | 3 |
| RTECS | XJ9095055 |
| HS Code | 2935904000 |
