Fosinopril Sodium , ≥99% , 88889-14-9

Synonym(s):
Fosinopril;Monopril;Secorvas;Staril;(2S,4S)-4-Cyclohexyl-1-(2-{[2-methyl-1-(propanoyloxy)propoxy](4-phenylbutyl)phosphoryl}acetyl)pyrrolidine-2-carboxylic acid

CAS NO.：88889-14-9

Empirical Formula: C30H46NNaO7P

Molecular Weight: 586.65

MDL number: MFCD00897699

EINECS: 1312995-182-4

PRODUCT Properties

• Melting point: 196-198°C
• storage temp.: Inert atmosphere,Store in freezer, under -20°C
• solubility: H2O: >20mg/mL
• form: powder
• color: white to off-white
• CAS DataBase Reference: 88889-14-9(CAS DataBase Reference)

Description and Uses

Fosinopril sodium, an ester prodrug of fosinoprilat, is the first of a new generation of phosphinic acid ACE inhibitors indicated for the once-daily treatment of hypertension. Unlike captopril and lisinopril, it is reportedly effective in increasing the left ventricular peak filling rates and peak ejection rates in hypertensive patients at rest. Another advantage is that fosinopril sodium is metabolized equally by renal and hepatic routes, thereby avoiding the requirement to modify dosage in patients with renal insufficiency.

A labelled phosphinic acid containing angiotensin converting enzyme (ACE) inhibitor.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Warning
• Hazard statements: H319-H361d
• Precautionary statements: P202-P264-P280-P305+P351+P338-P308+P313-P337+P313
• WGK Germany: 3
• HS Code: 2933995300