Benztropine mesylate , ≥98% , 132-17-2

Synonym(s):
Benzatropine mesylate;Benzatropine, Cogentin;Benzotropine mesylate;Benztropine mesylate;Benztropine methanesulfonate

CAS NO.：132-17-2

Empirical Formula: C22H29NO4S

Molecular Weight: 403.53

MDL number: MFCD00074784

EINECS: 205-048-8

PRODUCT Properties

• Melting point: 135 °C(lit.)
• storage temp.: Inert atmosphere,2-8°C
• solubility: H2O: soluble20mg/mL, clear
• form: powder
• color: white to beige
• Water Solubility: Soluble in water (81 mg/ml at 25°C), DMSO (50 mg/ml at 25°C), ethanol (81 mg/ml at 25°C), and ether (very slightly).
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
• LogP: 4.962 (est)
• CAS DataBase Reference: 132-17-2(CAS DataBase Reference)

Description and Uses

Benztropine mesylate (132-17-2) is a centrally acting M1?muscarinic acetylcholine receptor antagonist (Ki=0.59 nM, rat).1?Also inhibits the dopamine transporter (Ki=160 nM).2?Benztropine mesylate enhances remyelination and significantly decreases clinical severity in the experimental autoimmune encephalomyelitis model of relapsing-remitting multiple sclerosis alone or in combination with immunosuppressive agents.3?Inhibits hepatitis C virus infection.4

Benzotropine methanesulfonate is used to treat the symptoms of Parkinson?s disease and is currently in clincial trials for chronic back pain. It shows anti-muscarinic effects comparable to Atropine, and also demonstrates competitive anti-nicotinic action at the nAChR (nicotinic acetylcholine receptor).

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H302-H311+H331
• Precautionary statements: P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P311
• Hazard Codes: T
• Risk Statements: 23/24/25
• Safety Statements: 36/37/39-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: YM3150000
• HazardClass: 6.1
• HS Code: 2939800000