A8360512
VE-821 , ≥98% , 1232410-49-9
Synonym(s):
3-Amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide;3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide;VE821
CAS NO.：1232410-49-9
Empirical Formula: C18H16N4O3S
Molecular Weight: 368.41
MDL number: MFCD19443686
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB303.20 | In Stock |
|
| 25MG | RMB1039.20 | In Stock |
|
| 100MG | RMB2879.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 247-249°C |
| Boiling point: | 568.4±50.0 °C(Predicted) |
| Density | 1.394 |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (40 mg/ml) |
| form | powder |
| pka | 9.97±0.70(Predicted) |
| color | white to beige |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
Description and Uses
Ataxia-telangiectasia and Rad3-related protein (ATR) is a serine/threonine kinase that activates DNA processes related to the DNA damage response. VE-821 is an ATP-competitive inhibitor of ATR (IC50 = 26 nM). It augments DNA damage and cell death of cancer cells in response to radiation under normal and hypoxic conditions. VE-821 also sensitizes cancer cells to chemotherapy.
VE-821 has been used as an inhibitor of ATM- and Rad3-related (ATR) protein in human cancer cells.
