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A1410250

EHT1864 , ≥98%(HPLC) , 754240-09-0

Synonym(s):
5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride

CAS NO.:754240-09-0

Empirical Formula: C25H27F3N2O4S2HCl

Molecular Weight:

MDL number: MFCD11114384

Pack Size Price Stock Quantity
5mg RMB599.20 In Stock
10mg RMB959.20 In Stock
50mg RMB3999.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: >195°C (dec.)
storage temp.  2-8°C
solubility  H2O: soluble10mg/mL, clear
form  powder
color  white to beige
CAS DataBase Reference 754240-09-0

Description and Uses

EHT 1864 is an inhibitor of the Rac subfamily of Rho GTPases, that binds to Rac1, Rac1b, Rac2, and Rac3 with Kd values of 40, 50, 50, and 250 nM, respectively. It can reverse transformation of NIH 3T3 fibroblasts caused by constitutively activated Rac1, as well as Rac-dependent transformation caused by Tiam1 or Ras. EHT 1864 inhibits APP processing by γ-secretase, reducing Αβ40 and Αβ42 accumulation. It blocks breast cancer cell invasion in a collagen matrix assay and, at 10 μM, increases the size but decreases the density of dendritic spines of hippocampal neurons in culture.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  3

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