Home Categories Biochemical Engineering BIIB021
A1408312

BIIB021 , ≥98% , 848695-25-0

CAS NO.:848695-25-0

Empirical Formula: C14H15ClN6O

Molecular Weight: 318.76

MDL number: MFCD15528939

EINECS: 812-781-2

Pack Size Price Stock Quantity
5MG RMB238.40 In Stock
25MG RMB798.40 In Stock
100MG RMB2310.40 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 192-193℃
Boiling point: 588.5±60.0 °C(Predicted)
Density  1.50
storage temp.  -20°C
solubility  Soluble in DMSO (>25 mg/ml)
form  solid
pka 6.07±0.40(Predicted)
color  White
Stability: Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 montha.

Description and Uses

BIIB021 is a potent HSP90 inhibitor (IC50 = 30 nM HER-2 degradation).1 It inhibited the proliferation of MCF7 and BT474 breast cancer cell lines (IC50 = 100 nM for each).? BIIB021 has shown efficacy as a therapeutic in multiple cancer models.2-5

BIIB 021 an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Studies show that BIIB 021 adminisitration led to degradation of Hsp90 client proteins measured in tumor tissue and resulted in the inhibition of tumor growth in several human tumor xenograft models.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P271-P280
HS Code  2921490090

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