BX-795 , ≥97% , 702675-74-9

Synonym(s):
;BX-795 - CAS 702675-74-9 - Calbiochem;N-[3-[[5-iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-Pyrrolidinecarboxamide hydrochloride

CAS NO.：702675-74-9

Empirical Formula: C23H26IN7O2S

Molecular Weight: 591.47

MDL number: MFCD26406408

EINECS: 200-256-5

PRODUCT Properties

• Melting point: >163°C (dec.)
• Density: 1.644
• storage temp.: 2-8°C
• solubility: DMSO: soluble15mg/mL, clear
• form: powder
• pka: 12.57±0.70(Predicted)
• color: white to light brown
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
• InChIKey: VAVXGGRQQJZYBL-UHFFFAOYSA-N

Description and Uses

3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that phosphorylates and activates a range of other kinases, including PKB, PKA, and certain isoforms of PKC. BX-795 is a potent, ATP-competitive inhibitor of PDK1 in vitro (IC₅₀ = 11 nM) and in cells (IC₅₀ = 300 nM). At comparable concentrations, BX-795 also inhibits ERK8, MAPK-interacting kinase 2, Aurora B, Aurora C, MAP/microtubule affinity-regulating kinases 1-4, TNF receptor associated factor-associated NF-κB activator-binding kinase 1, IκB kinase ε, and additional kinases.

BX-795 hydrochloride has been used to study the effect of kinase inhibition on human endogenous retroviruses (HERVs) transcription activation.

Safety

• WGK Germany: 3