5-Bromouracil , 99% , 51-20-7

Synonym(s):
5-Bromo-2,4-dihydroxypyrimidine

CAS NO.：51-20-7

Empirical Formula: C4H3BrN2O2

Molecular Weight: 190.98

MDL number: MFCD00006017

EINECS: 200-084-0

PRODUCT Properties

• Melting point: >300 °C (lit.)
• Density: 1.8710 (rough estimate)
• refractive index: 1.6200 (estimate)
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• solubility: <1g/l
• pka: 6.77±0.10(Predicted)
• form: Solid
• color: White
• Water Solubility: SOLUBLE IN COLD WATER
• Merck: 14,1445
• BRN: 127176
• InChIKey: LQLQRFGHAALLLE-UHFFFAOYSA-N
• CAS DataBase Reference: 51-20-7(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromouracil(51-20-7)
• EPA Substance Registry System: 5-Bromouracil (51-20-7)

Description and Uses

5-bromouracil (5-BU) is a uracil derivative, and its 5' position of the pyrimidine ring is halogenated. If 5-BU is incorporated into DNA in place of thymine, the tautomeric shift will occur, and the 5-BU will base pair with guanine. After the replication, an A-T to G-C transition occurs. Furthermore, the presence of 5-BU within DNA increases the sensitivity of the molecule to UV light. 5-BU is structurally similar to thymine. Therefore, it is considered a thymine analog and base-pairs normally with adenine. It is rarely present in its enol form, where its base pairs with guanine. 5-Bromouracil treats neoplasms in the form of its nucleoside, 5-bromo-2-deoxy-uridine[1-2].

A major chemical mutagen. Incorporates into DNA, altering base-pair sequencing by replacing thymine

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H341
• Precautionary statements: P201-P202-P280-P308+P313-P405-P501a
• Hazard Codes: Xn
• Risk Statements: 22-46
• Safety Statements: 36/37-53-45-24/25
• WGK Germany: 3
• RTECS: YQ9060000
• TSCA: Yes
• HS Code: 29335995
• Hazardous Substances Data: 51-20-7(Hazardous Substances Data)