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A1192512

Bilobalide , Analysis standard , 33570-04-6

Synonym(s):
Bilobalide

CAS NO.:33570-04-6

Empirical Formula: C15H18O8

Molecular Weight: 326.3

MDL number: MFCD00238547

Pack Size Price Stock Quantity
10MG RMB558.40 In Stock
20mg RMB1007.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: >300°
alpha  57820 -64.3° (c = 2 in acetone)
Boiling point: 651.7±55.0 °C(Predicted)
Density  1.56±0.1 g/cm3(Predicted)
storage temp.  −20°C
solubility  Acetone (Slightly), Methanol (Slightly)
pka 11.74±0.40(Predicted)
form  Solid
color  White to Off-White
Merck  14,1220
Stability: Hygroscopic
LogP -0.450 (est)

Description and Uses

Bilobalide is a sesquiterpene lactone which is found in extracts of G. biloba. It has been shown to protect against cerebral edema, decrease cortical infarct volume, and reduce cerebral ischemic damage. Bilobalide, at 10 μM, reduces the release of glycine and glutamate from hippocampal slices under ischemic conditions. It also activates the rat constitutive androstane receptor at 100 μM and increases the levels and activities of several cytochrome P450 isoforms in rat liver microsomes.

Bilobalide provides protection against learning and memory impairment by reducing free radical injury and inhibiting neuronal apoptosis in the brain cortex and hippocampal CA1 region in induced vascular dementia rats.

Safety

Symbol(GHS) 
GHS05,GHS07,GHS09
Signal word  Danger
Hazard statements  H302-H315-H317-H318-H410
Precautionary statements  P261-P264-P270-P272-P273-P280-P301+P312+P330-P302+P352-P305+P351+P338+P310-P333+P313-P391-P501
Safety Statements  24/25
WGK Germany  3
RTECS  LV1665000
10
HS Code  29322090

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