Bafilomycin A1 , ≥95.0% , 88899-55-2

Synonym(s):
Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem

CAS NO.：88899-55-2

Empirical Formula: C35H58O9

Molecular Weight: 622.83

MDL number: MFCD06795130

EINECS: 621-324-4

PRODUCT Properties

• Melting point: >106°C (dec.)
• Boiling point: 582.86°C (rough estimate)
• Density: 1.0594 (rough estimate)
• refractive index: 1.5000 (estimate)
• RTECS: RN9781000
• Flash point: 87℃
• storage temp.: -20°C
• solubility: Soluble in DMSO (up to 5 mg/ml, with warming).
• pka: 12.66±0.70(Predicted)
• form: Powder or Solid
• color: White to off-white
• Water Solubility: Soluble in methanol, ethanol, acetone and chloroform. Insoluble in water.
• BRN: 4730700
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Description and Uses

Bafilomycin A₁ is a fungal metabolite that has been found in Streptomyces and has diverse biological activities. It is an inhibitor of vacuolar H⁺-ATPases (V-ATPases; K_i = 0.5 nM in N. crassa vacuolar membranes) and is greater than 1,000-fold selective for V-ATPases over Na⁺/K⁺-, Ca²⁺-, and H⁺-ATPases. Bafilomycin A₁ (100 nM) inhibits autophagosome maturation and protein degradation in H-4-II-E cells. It inhibits chloroquine-induced apoptosis in primary cerebellar granule neurons (CGNs) but not chloroquine-induced inhibition of macroautophagy. Bafilomycin A₁ (100 nM) reduces viral yield in the culture supernatant of Vero E6 and Huh7 cells, as well as HEK293T cells expressing human angiotensin-converting enzyme 2 (ACE2), infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It also reduces lung RNA copy numbers and viral pneumonia in ACE2 transgenic mice infected with SARS-CoV-2 when administered at a dose of 0.1 mg/kg.

A macrolide antibiotic and potent and selective inhibitor of vacuolar-type (v-type) H+ ATPase

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335-H227
• Precautionary statements: P210e-P280a-P370+P378a-P403+P235-P501a-P261-P304+P340-P305+P351+P338-P405
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 3172
• WGK Germany: 3
• F: 10
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29419090