Oligomycin A from Streptomyces diastatochromogenes , ≥97% , 579-13-5

CAS NO.：579-13-5

Empirical Formula: C45H74O11

Molecular Weight: 791.06

MDL number: MFCD00065705

EINECS: 209-437-3

PRODUCT Properties

• Melting point: 150-151℃
• Boiling point: 886.3±65.0 °C(Predicted)
• Density: 1.14
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• solubility: Soluble in DMSO, ethanol or acetone
• pka: 12.52±0.70(Predicted)
• form: powder
• color: white to off-white
• Merck: 13,6902
• BRN: 5702132
• InChIKey: MNULEGDCPYONBU-WMBHJXFZSA-N

Description and Uses

Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin A, a dominant analog of the isomers, is an inhibitor of mitochondrial F₁F_O ATP synthase that induces apoptosis in a variety of cell types (average GI₅₀ = 270 nM). Oligomycin A exhibits antifungal, antitumor, and nematocidal activities, but has poor solubility in water and other biocompatible solvents, which limits its clinical application.

Oligomycin A is the dominant analogue of a class of macrocyclic lactones isolated from selected strains of Streptomyces sp.. Oligomycin A is an inhibitor of mitochondrial F1F0-ATPase. It induces apoptosis in a variety of cell types, makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis. Oligomycin A exhibits a broad biological profile including antifungal, antitumor and nematocidal activities.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312a-P330-P501a
• Hazard Codes: Xn,T
• Risk Statements: 22-68/20/21/22-20/21/22
• Safety Statements: 36/37-24/25
• RIDADR: 2811
• WGK Germany: 3
• RTECS: RK3325000
• F: 3-10
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29419090