Thapsigargin , ≥95% , 67526-95-8
Synonym(s):
;InSolution Thapsigargin - CAS 67526-95-8 - Calbiochem;Thapsigargin - CAS 67526-95-8 - Calbiochem
CAS NO.：67526-95-8
Empirical Formula: C34H50O12
Molecular Weight: 650.75
MDL number: MFCD00083511
EINECS: 614-076-3
| Pack Size | Price | Stock | Quantity |
| 1MG | RMB799.20 | In Stock |
|
| 5MG | RMB3199.20 | In Stock |
|
| 10MG | RMB5599.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Boiling point: | 597.77°C (rough estimate) |
| Density | 1.1521 (rough estimate) |
| refractive index | 1.6390 (estimate) |
| RTECS | RH0325700 |
| storage temp. | -20°C |
| solubility | DMSO: soluble |
| form | liquid or film |
| pka | 10.57±0.70(Predicted) |
| color | Colorless |
| Sensitive | Light Sensitive |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week. |
| CAS DataBase Reference | 67526-95-8(CAS DataBase Reference) |
Description and Uses
Thapsigargin is a naturally occurring sesquiterpene lactone isolated from the umbelliferous plant Thapsia garganica. It is a non-competitive, cell permeable inhibitor of calcium transport by SERCAs (IC50 values are cell type-dependent and range from ~2-80 nM). This tumor promoter releases Ca2+ from intracellular stores by specifically inhibiting the endoplasmic reticulum Ca2+-ATPase; it does not directly affect plasma membrane Ca2+-ATPases, Ins 1,4,5-P3 production or protein kinase C activity. This effect is a result of emptying the intracellular calcium stores, which leads to a chain of events that causes apoptosis.
THAPSIGARGIN is a widely used inhibitor of the ubiquitous sarco-endoplasmic reticulum Ca(2+)-ATPases in mammalian cells. It acts as a potent, cell-permeable, IP3-independent intracellular calcium releaser that blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin. It induces apoptosis by disrupting intracellular free Ca2+ levels.
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H315-H319-H334-H335 |
| Precautionary statements | P261-P264-P271-P302+P352-P304+P340+P312-P305+P351+P338 |
| Hazard Codes | Xn,T |
| Risk Statements | 36/37/38-42 |
| Safety Statements | 26-36/37/39 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| HS Code | 29181990 |
