Albendazole , ≥98% , 54965-21-8

Synonym(s):
Albendazole;Methyl 5-(propylthio)-2-benzimidazolecarbamate

CAS NO.：54965-21-8

Empirical Formula: C12H15N3O2S

Molecular Weight: 265.33

MDL number: MFCD00083232

EINECS: 259-414-7

PRODUCT Properties

• Melting point: 208-210 °C
• Density: 1.2561 (rough estimate)
• refractive index: 1.6740 (estimate)
• storage temp.: 2-8°C
• solubility: Practically insoluble in water, freely soluble in anhydrous formic acid, very slightly soluble in methylene chloride, practically insoluble in ethanol (96 per cent).
• form: Solid
• pka: 10.72±0.10(Predicted)
• color: White to Off-White
• Water Solubility: 0.75mg/L(209 ºC)
• Merck: 14,210
• BCS Class: 4
• InChI: InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
• InChIKey: HXHWSAZORRCQMX-UHFFFAOYSA-N
• SMILES: C(OC)(=O)NC1NC2=CC(SCCC)=CC=C2N=1
• CAS DataBase Reference: 54965-21-8(CAS DataBase Reference)

Description and Uses

Albendazole is a derivative of benzimidazole, is a drug with a broad antihelmintic spectrum. It exhibits an antihelmintic effect against sensitive cestodes and nematodes by blocking the process of glucose uptake by the parasites, which is expressed in the depletion of glycogen reserves and subsequent reduction in the level of adenosintriphophate. As a result, the parasite stops moving and dies. It is used upon infection of Acaris lumbricoides, Ancylostoma duodenale, Necator americanus, Enterobius vermicularis, and Trichuris trichiura. Synonyms of this drug are SKF 62979 and others.

Safety

• Symbol(GHS): GHS08,GHS09
• Signal word: Warning
• Hazard statements: H361d-H373-H410
• Precautionary statements: P202-P260-P273-P280-P308+P313-P391
• Hazard Codes: T,Xn
• Risk Statements: 61-36/37/38-48/22-63-33
• Safety Statements: 53-45-37/39-26-36/37-24/25
• WGK Germany: 2
• RTECS: FD1100000
• HS Code: 29332990
• Hazardous Substances Data: 54965-21-8(Hazardous Substances Data)