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A5015612

Imidazole , Melting point standard , 288-32-4

Synonym(s):
Imidazole;Glyoxaline;Glyoxaline solution;Glyoxaline, 1;Glyoxaline, Iminazole

CAS NO.:288-32-4

Empirical Formula: C3H4N2

Molecular Weight: 68.08

MDL number: MFCD00005183

EINECS: 206-019-2

Pack Size Price Stock Quantity
2G RMB287.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 88-91 °C(lit.)
Boiling point: 256 °C(lit.)
Density  1.01 g/mL at 20 °C
vapor pressure  <1 mm Hg ( 20 °C)
refractive index  1.4801
Flash point: 293 °F
storage temp.  Store below +30°C.
solubility  H2O: 0.1 M at 20 °C, clear, colorless
form  crystalline
pka 6.953(at 25℃)
color  white
Specific Gravity 1.03
Odor Amine like
PH Range 9.5 - 11
PH 9.5-11.0 (25℃, 50mg/mL in H2O)
Water Solubility  633 g/L (20 ºC)
Sensitive  Hygroscopic
λmax λ: 260 nm Amax: 0.10
λ: 280 nm Amax: 0.10
Merck  14,4912
BRN  103853
Dielectric constant 23.0(Ambient)
Stability: Stable. Incompatible with acids, strong oxidizing agents. Protect from moisture.
InChIKey RAXXELZNTBOGNW-UHFFFAOYSA-N
LogP -0.02 at 25℃

Description and Uses

Imidazole group denotes a heterocyclic organic compound whose molecule contains a five-membered hetero-aromatic ring of two non-adjacent nitrogen atoms, that a carbon atom is placed between two nitrogen atoms. Imidazole is the universally used trivial name for 1,3-azole. Earlier given names were glyoxaline and iminazole. The importance of this aromatic ring system is reflected by its presence in naturally occurring histidine, histamine and the purines, and in several classes of pharmaceuticals. Imidazole can act as a base and as a weak acid. It exists in two tautomeric forms with the hydrogen atom taking position between the two nitrogen atoms.

Imidazole is used as a buffer in the range of pH 6.2-7.8. It is also an histamine antagonist. It acts as a chelator and forms complexes with various divalent cations. It is used as a corrosion inhibitor on certain transition metals such as copper. Its derivatives, like polybenzimidazole (PBI), act as fire retardants. It finds application in photography and electronics. Imidazole salts are used as ionic liquids and precursors to stable carbenes. Imidazole derivatives like ketoconazole, miconazole and clotrimazole are involved in the treatment of various systemic fungal infections. It is a part of the theophylline molecule, present in tea leaves and coffee beans, which stimulates the central nervous system.

Safety

Symbol(GHS) 
GHS05,GHS07,GHS08
Signal word  Danger
Hazard statements  H302-H314-H360D
Precautionary statements  P260-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  C,Xi,T
Risk Statements  36/38-63-34-22-20/21/22-61
Safety Statements  26-36/37/39-45-22-36-27-53
RIDADR  UN 2923 8/PG 3
WGK Germany  1
RTECS  NI3325000
Autoignition Temperature 480 °C
TSCA  Yes
HazardClass  8
PackingGroup  III
HS Code  29332990
Toxicity LD50 in mice (mg/kg): 610 i.p.; 1880 orally (Nishie)

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