A0771912
ABT-751 (E7010) , ≥98% , 141430-65-1
CAS NO.：141430-65-1
Empirical Formula: C18H17N3O4S
Molecular Weight: 371.41
MDL number: MFCD00910291
EINECS: 256-495-9
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB287.20 | In Stock |
|
| 50MG | RMB1199.20 | In Stock |
|
| 100MG | RMB1999.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 162 °C(dec.) |
| Boiling point: | 551.0±60.0 °C(Predicted) |
| Density | 1.427 |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | insoluble in H2O; ≥18.55 mg/mL in DMSO; ≥25.53 mg/mL in EtOH with ultrasonic |
| form | powder to crystal |
| pka | 7.86±0.40(Predicted) |
| color | White to Yellow to Orange |
Description and Uses
ABT-751 is a tubulin polymerization inhibitor that binds to the colchicine binding site on β-tubulin (Ki = 3.3 μM). It inhibits tubulin polymerization in a concentration-dependent manner and inhibits growth of 26 human tumor cell lines (IC50s = 0.06-0.08 μg/ml). ABT-751 (100 mg/kg, p.o.) induces tumor regression in NB-1382 neuroblastoma, IRS56 rhabdomyosarcoma, and KT-6 Wilms mouse xenograft models. It also induces tumor endothelial cell retraction and reduces tumor perfusion, but not muscle perfusion, in a 9L rat glioma subcutaneous tumor model.
Safety
| Symbol(GHS) |   GHS08,GHS07 |
| Signal word | Warning |
| Hazard statements | H361-H302-H373 |
| Precautionary statements | P260-P314-P501-P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P312-P330-P501 |
| RTECS | DB2734000 |
| HS Code | 2935.90.9500 |
