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A7709358

Fosbretabulindisodium , 10mMinWater , 168555-66-6

Synonym(s):
2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl disodium phosphate;CA4P;Combretastatin A4 phosphate disodium

CAS NO.:168555-66-6

Empirical Formula: C18H19O8P.2Na

Molecular Weight: 440.29

MDL number: MFCD00943911

EINECS: 1312995-182-4

Pack Size Price Stock Quantity
1ml RMB559.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 238-242 ºC
storage temp.  -20°C
solubility  H2O: soluble5mg/mL, clear
form  powder
color  white to beige
InChIKey VXNQMUVMEIGUJW-XNOMRPDFSA-L

Description and Uses

Combretastatin A4 phosphate disodium salt, also known as fosbretabulin disodium or CA4P, is a microtubule destabilizing drug, a water-soluble prodrug of combretasain a4(ca4) and a tumor vascular-targeting agent.microtubule is the cylindrical and filamentous structure that required for cell shape, migration, cilia and flagella mobility etc. tubulin is the major component of microtubulesin proliferative endothelial cells, ca4p (dose less than 1/10 of the max. tolerated dose) leaded to tumor vascular shutdown, and short drug exposure of ca4p caused significant long-term anti-proliferative and cytotoxic effects. [1] in ca40 treated endothelia cell, myosin light chain was phosphorylated and lead to actinomyosin contractility, assembly of actin stress fibers and focal adhesions formation. [2] in huvec cells, ca4p blocked growth factor–induced endothelial cell proliferation and migration and impaired capillary tube formation. [3]in c57bl/6 mice, ca4p treatment in combination with mab against ve-cardherin facilitated b16 melanoma tumor necrosis and inhibited tumor neoangionesis. [3] in human breast cancer models in vivo, 6 hours after ca4p administration showed a 93% decreased functional vascular volume and lasted over the next 12 hours. [1]

Safety

WGK Germany  3
HS Code  2919.90.3000

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