Home Categories Chemical Reagents Combretastatin A4
A2578012

Combretastatin A4 , >98.0%(HPLC) , 117048-59-6

Synonym(s):
1-(3,4,5-Trimethoxyphenyl)-2-(3′-hydroxy-4′-methoxyphenyl) ethane 3,4,5-trimethoxy-3′-hydroxy-4′-methoxystilbene;2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol;CA4;Combretastatin A-4 - CAS 117048-59-6 - Calbiochem;Combretastatin A4, CA4, Tubulin Polymerization Inhibitor XVIII, NSC 817373, 2-Methoxy-5-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-phenol, CA-4

CAS NO.:117048-59-6

Empirical Formula: C18H20O5

Molecular Weight: 316.35

MDL number: MFCD03453309

Pack Size Price Stock Quantity
5mg RMB57.60 In Stock
25MG RMB87.20 In Stock
100MG RMB288.80 In Stock
250MG RMB594.40 In Stock
500mg RMB1023.20 In Stock
1g RMB1869.60 In Stock
others     Enquire
Update time: 2022-07-08

PRODUCT Properties

Melting point: 84.5-85.5°C
Boiling point: 490.3±45.0 °C(Predicted)
Density  1.184±0.06 g/cm3(Predicted)
storage temp.  -20°C
solubility  DMSO: >10mg/mL
form  powder
pka 9.65±0.10(Predicted)
color  off-white
Merck  14,2494

Description and Uses

Combrestatin A4 (CA4) is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. Combrestatin A4 was shown to inhibit tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-1 (pancreatic carcinoma), and MCF-7 (breast cancer) with IC50 values of 2.16, 5.20, 3.46, and 18.47 nM, respectively. CA4 inhibits tubulin polymerization with an IC50 value of 2.2 μM.

Combretastatin A4 has been used:

  • as an anti-tubulin agent to determine the effects of isocitrate dehydrogenases (IDH1 and IDH2) proteins in G2/M phase
  • to evaluate the anti-proliferative and pro-apoptotic properties of biphenyl CA4 derivatives in both 2D and 3D cancerous and non-cancerous cell models
  • as a microtubule inhibitor to study its effects on motility of Ascaris suum L3 larvae

Safety

Symbol(GHS) 
GHS05,GHS06
Signal word  Danger
Hazard statements  H301+H311+H331-H318
Precautionary statements  P261-P280-P301+P310-P302+P352+P312-P304+P340+P311-P305+P351+P338
Hazard Codes  T
Risk Statements  23/24/25-41
Safety Statements  26-36/37-39-45
RIDADR  UN 2811
WGK Germany  2
HazardClass  6.1
PackingGroup 
HS Code  29095000

RELATED PRODUCTS