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A6213212

Nocodazole , ≥98% , 31430-18-9

Synonym(s):
[5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamic acid methyl ester;Methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate;Methyl N-(5-thenoyl-2-benzimidazolyl)carbamate;Oncodazole

CAS NO.:31430-18-9

Empirical Formula: C14H11N3O3S

Molecular Weight: 301.32

MDL number: MFCD00005588

EINECS: 250-626-5

Pack Size Price Stock Quantity
10MG RMB239.20 In Stock
50MG RMB639.20 In Stock
250mg RMB1919.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 300 °C (dec.)
Density  1.490
refractive index  1.6740 (estimate)
storage temp.  -20°C
solubility  DMSO: 10 mg/mL, soluble
form  powder
pka 10.67±0.10(Predicted)
color  white
BRN  1085978
Stability: Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChIKey KYRVNWMVYQXFEU-UHFFFAOYSA-N
CAS DataBase Reference 31430-18-9(CAS DataBase Reference)
EPA Substance Registry System Nocodazole (31430-18-9)

Description and Uses

Nocodazole reversibly binds tubulin and alters tubulin-associated GTP hydrolysis as well as microtubule dynamics. While nocodazole is used to study many aspects on microtubule function, it is most commonly used to synchronize cell cycling in culture. Typically, nanomolar concentrations of nocodazole reduce both microtubule elongation and shortening velocities, resulting in arrest of cycling in a G2/M phase. Nocodazole is also used to induce the formation of Golgi ministacks in eukaryotic cells.

Nocodazole has been shown to enhance CRISPR genome editing efficiency. To see other small molecule CRISPR enhancers, visit sigma.com/CRISPR-enhancers.

Safety

Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H341-H361d
Precautionary statements  P201-P202-P280-P308+P313-P405-P501
Hazard Codes  T,C,F,Xn
Risk Statements  61-40-36/37/38-34-11-68-63
Safety Statements  53-45-36/37/39-26-16-36/37
RIDADR  2811
WGK Germany  3
RTECS  DD6521000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29349990
Toxicity sln-smc 1 ppm/16H MUREAV 141,15,84

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