Hydroxyurea , 98% , 127-07-1

Synonym(s):
Hydroxycarbamide;Hydroxyurea;Hydroxyurea - CAS 127-07-1 - Calbiochem;Ribonucleotide Reductase Inhibitor I, RNR Inhibitor I

CAS NO.：127-07-1

Empirical Formula: CH4N2O2

Molecular Weight: 76.05

MDL number: MFCD00007943

EINECS: 204-821-7

PRODUCT Properties

• Melting point: 135-140 °C
• Boiling point: 136.04°C (rough estimate)
• Density: 1.457±0.06 g/cm3(Predicted)
• refractive index: 1.4840 (estimate)
• storage temp.: 2-8°C
• solubility: H₂O: 50 mg/mL
• form: powder
• pka: 10.56±0.23(Predicted)
• color: white
• Odor: odorless or almost odorless
• Water Solubility: soluble
• Merck: 14,4848
• BRN: 1741548
• Stability: Stable for 2 years as supplied from date of purchase. Solutions in water may be stored at -20°C for up to 3 months.

Description and Uses

Readily oxidized in vivo to free radical forms, which destroy the stable tyrosyl free radical of the metalloenzyme ribonucleotide reductase, suppressing deoxyribonucleotide production and blocking DNA synthesis and repair.1,2 Reduces cell proliferation, and causes S-phase arrest and death.3 Induces p53-dependent NF-κB target gene expression in U2OS cells expressing HA-RelA.4 Stimulates fetal hemoglobin production in vitro and in vivo.5 Allows for S phase enrichment of CHO cells with maintenance of viability for enhanced site-specific genome engineering.6 Anticancer and antiviral agent.

antineoplastic, inhibits ribonucleoside diphosphate reductase

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H340-H361
• Precautionary statements: P201-P308+P313
• Hazard Codes: T,Xn
• Risk Statements: 46-63-61-40
• Safety Statements: 53-36/37-45-36-22
• RIDADR: 2811
• WGK Germany: 3
• RTECS: YT4900000
• Hazard Note: Toxic
• HazardClass: 6.1
• PackingGroup: III
• HS Code: 29242100
• Toxicity: dog,LD50,intravenous,> 1gm/kg (1000mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992.