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A4704012

Hydroxyurea , 98% , 127-07-1

Synonym(s):
Hydroxycarbamide;Hydroxyurea;Hydroxyurea - CAS 127-07-1 - Calbiochem;Ribonucleotide Reductase Inhibitor I, RNR Inhibitor I

CAS NO.:127-07-1

Empirical Formula: CH4N2O2

Molecular Weight: 76.05

MDL number: MFCD00007943

EINECS: 204-821-7

Pack Size Price Stock Quantity
1G RMB24.00 In Stock
5G RMB31.20 In Stock
25G RMB39.20 In Stock
100G RMB103.20 In Stock
500g RMB319.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 135-140 °C
Boiling point: 136.04°C (rough estimate)
Density  1.457±0.06 g/cm3(Predicted)
refractive index  1.4840 (estimate)
storage temp.  2-8°C
solubility  H2O: 50 mg/mL
form  powder
pka 10.56±0.23(Predicted)
color  white
Odor odorless or almost odorless
Water Solubility  soluble
Merck  14,4848
BRN  1741548
Stability: Stable for 2 years as supplied from date of purchase. Solutions in water may be stored at -20°C for up to 3 months.
CAS DataBase Reference 127-07-1(CAS DataBase Reference)
IARC 3 (Vol. 76) 2000
EPA Substance Registry System Hydroxyurea (127-07-1)

Description and Uses

Readily oxidized in vivo to free radical forms, which destroy the stable tyrosyl free radical of the metalloenzyme ribonucleotide reductase, suppressing deoxyribonucleotide production and blocking DNA synthesis and repair.1,2 Reduces cell proliferation, and causes S-phase arrest and death.3 Induces p53-dependent NF-κB target gene expression in U2OS cells expressing HA-RelA.4 Stimulates fetal hemoglobin production in vitro and in vivo.5 Allows for S phase enrichment of CHO cells with maintenance of viability for enhanced site-specific genome engineering.6 Anticancer and antiviral agent.

antineoplastic, inhibits ribonucleoside diphosphate reductase

Safety

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H340-H361
Precautionary statements  P201-P308+P313
Hazard Codes  T,Xn
Risk Statements  46-63-61-40
Safety Statements  53-36/37-45-36-22
RIDADR  2811
WGK Germany  3
RTECS  YT4900000
Hazard Note  Toxic
HazardClass  6.1
PackingGroup  III
HS Code  29242100
Hazardous Substances Data 127-07-1(Hazardous Substances Data)
Toxicity dog,LD50,intravenous,> 1gm/kg (1000mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992.

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