1,1'-(Azodicarbonyl)dipiperidine , >98.0% , 10465-81-3
Synonym(s):
1,1′-Azobis(N,N-pentamethyleneformamide);ADD;Azodicarboxylic acid dipiperidide;NSC 356027;SR 4077
| Pack Size | Price | Stock | Quantity |
| 1G | RMB24.00 | In Stock |
|
| 5G | RMB88.80 | In Stock |
|
| 25G | RMB312.80 | In Stock |
|
| 100G | RMB960.80 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 132-136 °C(lit.) |
| Boiling point: | 366.4±25.0 °C(Predicted) |
| Density | 1.29±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | -0?+-.0.20(Predicted) |
| form | solid |
| color | yellow |
| Water Solubility | Slightly soluble in water. |
| BRN | 261917 |
| InChI | InChI=1S/C12H20N4O2/c17-11(15-7-3-1-4-8-15)13-14-12(18)16-9-5-2-6-10-16/h1-10H2 |
| InChIKey | OQJBFFCUFALWQL-UHFFFAOYSA-N |
| SMILES | N(C(N1CCCCC1)=O)=NC(N1CCCCC1)=O |
Description and Uses
1,1''-(Azodicarbonyl)dipiperidine (ADDP) is a reagent commonly used in the Mitsunobu reaction for the condensation of an alcohol and an acidic compound. It has been used as a reagent in the synthesis of G protein-coupled receptor 120 (GPR120) agonists with antidiabetic activity and peroxisome proliferator-activated receptor α (PPARα), PPARγ, and PPARδ triple agonists.
It is used in a study of the copper-catalyzed addition of aryboronic acids to azodicarboxyl derivatives providing aryl-substituted hydrazides. It is widely used reagent for the Mitsunobu reaction. It is reactant for preparation of polyfluoroalkylated tripyrazolylmethane ligands, (-)-Hygromycin A via Mitsunobu glycosylation, optically active α,α-disubstituted amino acids via Mitsunobu reaction, aza-β-lactams through [2+2] cycloaddition reactions, glycosyl disulfides, pyridine ether PPAR agonists, S-glycosyl amino acid, building blocks for combinatorial neoglycopeptide synthesis and is a histamine H3 receptor antagonists. It is a reactant for Mitsunobu inversion reactions.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | 3234 |
| WGK Germany | 3 |
| TSCA | No |
| HS Code | 29339900 |
