5-Aza-2′-deoxycytidine , 98% , 2353-33-5

Synonym(s):
2′-Deoxy-5-azacytidine;4-Amino-1-(2-deoxy-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one;5-Aza-CdR, 5-Aza-dC, 2′-Deoxy-5-azacytidine, Decitabine;Decitabine;InSolution

CAS NO.：2353-33-5

Empirical Formula: C8H12N4O4

Molecular Weight: 228.21

MDL number: MFCD00043011

EINECS: 219-089-4

PRODUCT Properties

• Melting point: ~200 °C (dec.)
• alpha: D22 +68.5° (30 min) +57.8° (6 hr) (c = 0.5 in water)
• Boiling point: 370.01°C (rough estimate)
• Density: 1.3771 (rough estimate)
• refractive index: 1.6590 (estimate)
• storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• solubility: acetic acid/water (1:1): 50 mg/mL
• pka: 14.02±0.60(Predicted)
• form: Powder
• color: White to Off-white
• Merck: 14,2853
• BRN: 617982
• Stability: Stable. May be light or air sensitive. Incompatible with strong oxidizing agents.
• InChIKey: XAUDJQYHKZQPEU-KVQBGUIXSA-N

Description and Uses

Decitabine, 5-aza-2’-deoxycytidine, has been launched for the treatment of myelodysplastic syndromes (MDS). MDS are a set of hematologic disorders affecting the bone marrow that result in ineffective formation and development of blood cells. Furthermore, patients with MDS have a high risk of progressing to acute myeloid leukemia (AML). Traditional treatments include blood transfusions, hematopoietic growth factors, and prophylactic antibiotics, but these measures merely improve the quality of life with questionable effects on disease modification. While stem-cell transplantation is an aggressive, potentially curative approach, the advanced age or the other complicating health issues of most patients preclude them from considering this option. Recent advances in the underlying etiology of MDS, however, have led to the development of a new class of compounds known as ‘‘demethylating agents’’. Decitabine follows the successful introduction of the first DNA methyltransferase inhibitor azacitidine.

Used as cancer treatment, in particular to inhibit the growth of pancreatic endocrine tumor cell lines.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H302-H315-H319-H335-H341-H360
• Precautionary statements: P201-P202-P301+P312-P302+P352-P305+P351+P338-P308+P313
• Hazard Codes: Xn,Xi,T
• Risk Statements: 22-36/37/38-68-61
• Safety Statements: 26-36-36/37
• WGK Germany: 3
• RTECS: XZ3012000
• F: 10-34
• HS Code: 29349990
• Toxicity: LD50 in mice (mg/kg): 190 i.p. (Momparler, 1985)