2′-Deoxycytidine monohydrate , 99% , 951-77-9

CAS NO.：951-77-9

Empirical Formula: C9H13N3O4

Molecular Weight: 227.22

MDL number: MFCD00006547

EINECS: 213-454-1

PRODUCT Properties

• Melting point: 209-211 °C(lit.)
• Boiling point: 368.93°C (rough estimate)
• Density: 1.3171 (rough estimate)
• refractive index: 59 ° (C=1, H2O)
• storage temp.: -20°C
• solubility: H₂O: 50 mg/mL, clear, colorless
• form: Crystalline Powder
• pka: 14.03±0.60(Predicted)
• color: White
• PH: 4.3
• Water Solubility: Soluble in water, DMSO.
• λmax: 280 (pH 1)；271 (pH 7)
• BRN: 87567
• InChI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1
• InChIKey: CKTSBUTUHBMZGZ-SHYZEUOFSA-N
• SMILES: OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)C[C@@H]1O
• CAS DataBase Reference: 951-77-9(CAS DataBase Reference)
• NIST Chemistry Reference: Deoxycytidine(951-77-9)
• EPA Substance Registry System: Cytidine, 2'-deoxy- (951-77-9)

Description and Uses

2'-Deoxycytidine is a deoxyribonucleotide that is used in the synthesis of DNA. 2'-Deoxycytidine has been shown to inhibit the kinase activity of IL-2 receptor and Toll-like receptor, which are proteins that regulate the immune response. 2'-Deoxycytidine also inhibits DNA polymerase activity and thermal expansion, which may make it a good candidate as an anticancer drug.

2'-Deoxycytidine (deoxyC) is one of the deoxynucleosides which after phosphorylation to dCTP is used to synthesis DNA via various DNA polymerases or reverse transcriptases. 2'-Deoxycytidine (deoxyC) is the substrate for deoxycytidine deaminase (EC 3.5.4.14) which converts it into 2?-deoxyuridine. 2?-Deoxycytidine is phosphorylated to the nucleotide dCMP by the enzyme deoxycytidine kinase (DCK).

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P280-P302+P352-P304+P340
• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: HA3800000
• F: 10
• TSCA: Yes
• HS Code: 29349990