PRODUCT Properties
| Melting point: | 238-240 °C |
| Boiling point: | 352.31°C (rough estimate) |
| Density | 1.8232 (rough estimate) |
| refractive index | 1.4813 (estimate) |
| storage temp. | Refrigerator |
| solubility | DMSO (Sparingly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 5.54±0.33(Predicted) |
| color | Off-White to Light Orange |
| Water Solubility | 21.5mg/L(temperature not stated) |
| CAS DataBase Reference | 87-87-6(CAS DataBase Reference) |
| EPA Substance Registry System | 2,3,5,6-Tetrachlorohydroquinone (87-87-6) |
Description and Uses
Tetrachlorohydroquinone (TCHQ) is a metabolite of the organochlorine biocide pentachlorophenol. It is cytotoxic to RTL-W1 rainbow trout liver cells (EC50 = 1.55 μM in a neutral red assay). TCHQ increases production of reactive oxygen species (ROS), inhibits apoptosis, and induces loss of the mitochondrial membrane potential and necrosis in splenocytes. In vivo, TCHQ induces glutathione (GSH) depletion in mouse liver.
Tetrachlorohydroquinone is a chlorinated hydroquinone compound used as an analytical standard.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P264-P270-P280-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501 |
| Hazard Codes | Xn |
| Risk Statements | 22-41 |
| Safety Statements | 26-36/37/39-39 |
| RTECS | MX7700000 |
| HS Code | 2914.79.4000 |
