Methyl Dichlorophosphite [Phosphitylating Agent] , >95.0%(T) , 3279-26-3

Synonym(s):
Methyl phosphorodichloridite

CAS NO.：3279-26-3

Empirical Formula: CH3Cl2OP

Molecular Weight: 132.91

MDL number: MFCD00000524

EINECS: 221-915-3

PRODUCT Properties

• Melting point: -91 °C (lit.)
• Boiling point: 93-95 °C (lit.)
• Density: 1.376 g/mL at 20 °C (lit.)
• refractive index: n20/D 1.474(lit.)
• Flash point: 104 °F
• storage temp.: −20°C
• solubility: soluble in Chloroform, Dichloromethane, Ethyl Acetate
• form: liquid
• color: Colorless to Almost colorless
• Water Solubility: Reacts with water. Soluble in chloroform, dichloromethane and ethyl acetate.
• Sensitive: Moisture Sensitive
• BRN: 1697452
• Stability: Flammable.

Description and Uses

Methyl dichlorophosphite has been employed in the preparation of:

• phosphonamidate- and phosphonate-linked phosphonopeptides
• 2-(2-iodophenyl)ethyl methyl phosphite derivative of an alcohol
• deoxyoligonucleotides on a polymer support
• cis- and trans-2-oxo-2-propionyl-1,3,2-oxazaphosphorinane
• phosphorodichloridothioates
• oxazaphosphorinanes

Safety

• Symbol(GHS): GHS02,GHS05,GHS07
• Signal word: Danger
• Hazard statements: H226-H314-H335
• Precautionary statements: P210-P233-P240-P280-P303+P361+P353-P305+P351+P338
• Hazard Codes: C
• Risk Statements: 10-14-34-37
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2920 8/PG 2
• WGK Germany: 3
• F: 10-13-23
• HazardClass: 8
• PackingGroup: II
• HS Code: 29209090