Etomidate , >98.0%(GC) , 33125-97-2
Synonym(s):
(R)-1-(α-Methylbenzyl)imidazole-5-carboxylic acid ethyl ester;Amidate;R16659
CAS NO.：33125-97-2
Empirical Formula: C14H16N2O2
Molecular Weight: 244.29
MDL number: MFCD00869295
EINECS: 251-385-9
PRODUCT Properties
| Melting point: | 72-74°C |
| alpha | D20 +66° (c = 1 in ethanol) |
| Boiling point: | 160-162 °C(Press: 1 Torr) |
| Density | 1.11±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >10 mg/mL |
| form | powder |
| pka | pKa 4.24(H2O t=25.0) (Uncertain) |
| color | white |
| Merck | 14,3881 |
Description and Uses
Etomidate , ethyl (R)-(+)-1(α- methylbenzyl)-imidazole-5-carboxylate, Mr 224.28, is a white to yellowish crystalline or amorphous powder. It is insoluble in water at pH 7, but soluble in acidic aqueous solutions at pH<3. Etomidate is soluble in propylene glycol and readily soluble in alcohol.
Etomidate is a GABAA receptors agonist with short-acting sedative, hypnotic, and general anesthetic properties. It is a unique drug used for induction of general anesthesia and sedation. It is also a hypnotic. Hypnotic effect of Etomidate is strong , and its efficacy is about 12 times higher than thiopental, it has no analgesic effect.
Safety
| Symbol(GHS) |   GHS07,GHS09 |
| Signal word | Warning |
| Hazard statements | H302-H400 |
| Precautionary statements | P301+P312+P330 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 36 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS | NI4021500 |
| HazardClass | 9 |
| PackingGroup | III |
| HS Code | 29332900 |
| Toxicity | LD50 in mice, rats (mg/kg): 29.5, 14.8-24.3 i.v. (Janssen) |
