T8563030
Digoxin , >96.0%(HPLC) , 20830-75-5
Synonym(s):
12β-Hydroxydigitoxin;Digoxin
CAS NO.：20830-75-5
Empirical Formula: C41H64O14
Molecular Weight: 780.95
MDL number: MFCD00003674
EINECS: 244-068-1
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 248 °C |
| alpha | 25Hg +13.4 to 13.8° (c = 10 in pyridine) |
| Boiling point: | 661.93°C (rough estimate) |
| Density | 1.1110 (rough estimate) |
| refractive index | 12 ° (C=10, Pyridine) |
| Flash point: | 9℃ |
| storage temp. | Refrigerator |
| solubility | Soluble in dimethyl sulfoxide and methanol. |
| form | powder |
| pka | 13.50±0.70(Predicted) |
| color | White to Almost white |
| Water Solubility | 46.08mg/L(room temperature) |
| Merck | 14,3167 |
| BRN | 77011 |
| BCS Class | 1 (LogP),
3 (CLogP) |
| LogP | 1.260 |
Description and Uses
Digoxin, 3β,14β-dihydroxy-5β-card-20(22)-enolide-3-rigitoxide, is also a glycoside isolated from various types of foxgloves. It differs from digitoxin in that it has an additional hydroxyl group at C16 of the steroid skeleton. It is extracted form the leaves of Digitalis lanta, Digitalis orientalis, or Scrophulariaceae.
cardiac stimulant
Safety
| Symbol(GHS) |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H300-H331-H373 |
| Precautionary statements | P260-P264-P270-P301+P310-P304+P340+P311-P314 |
| Hazard Codes | T,T+,F |
| Risk Statements | 25-26/27/28-23/25-39/23/24/25-23/24/25-11-28-26 |
| Safety Statements | 22-36/37/39-45-36/37-16-28A |
| RIDADR | UN 3462 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | IH6125000 |
| F | 3-10 |
| TSCA | Yes |
| HazardClass | 6.1 |
| PackingGroup | II |
| HS Code | 29389090 |
| Toxicity | cat,LD50,oral,200ug/kg (0.2mg/kg),Archives Internationales de Pharmacodynamie et de Therapie. Vol. 159, Pg. 1, 1966. |
