Pyruvic-1-13Cacid , APIforClinicalStudies,≥99atom%13C , 99124-30-8

Synonym(s):
11β,17α,21-Trihydroxypregn-4-ene-3,20-dione-D₄;11β,17α,21-Trihydroxypregn-4-ene-3,20-dione-d₄ (9,11,12,12-d₄);17-Hydroxycorticosterone-9,11,12,12-d₄;17-Hydroxycorticosterone-D₄;4-Pregnene-11β,17α,21-triol-3,20-dione-D₄

CAS NO.：99124-30-8

Empirical Formula: C21H26D4O4

Molecular Weight: 350.49

MDL number: MFCD00144010

EINECS: 694-327-1

PRODUCT Properties

• Melting point: 211-214 °C
• Flash point: 9℃
• storage temp.: -20°C Freezer
• solubility: DMSO (Slightly), Ethanol (Slightly, Heated), Methanol (Slightly, Heated), Water
• form: Solid
• color: White to Off-White

Description and Uses

Hydrocortisone-d₄ is intended for use as an internal standard for the quantification of hydrocortisone/cortisol by GC- or LC-MS. Cortisol, known as hydrocortisone when used as a therapeutic, is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH). It is an agonist at the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR), with an approximately 6- to 10-fold greater affinity for MR. Cortisol production is increased during periods of stress, and it is a major effector molecule in the hypothalamic-pituitary-adrenal axis (HPA) stress response. Cortisol levels increase with age and are often elevated in major depressive disorder, certain forms of hypertension, and Parkinson''s disease.

Anti-inflammatory hormone

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H361
• Precautionary statements: P201-P202-P280-P308+P313-P405-P501
• Hazard Codes: Xn,T,F
• Risk Statements: 63-39/23/24/25-23/24/25-11
• Safety Statements: 36/37-45-16-7
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 3